Muscle Cell News Volume 6.32 | Sep 20 2021

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    2021-09-20 | MUSCN 6.32


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.32 – 20 September, 2021
    TOP STORY

    RARG Variant Predictive of Doxorubicin-Induced Cardiotoxicity Identifies a Cardioprotective Therapy

    Researchers showed that human induced pluripotent stem cell-derived cardiomyocytes from patients with rs2229774 and who suffered doxorubicin-induced cardiotoxicity were more sensitive to doxorubicin.
    [Current Biology]

    AbstractGraphical Abstract

    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    MicroRNA-26a/B-5p Promotes Myocardial Infarction-Induced Cell Death by Downregulating Cytochrome C Oxidase 5a

    Investigators found that cytochrome c oxidase subunit 5a expression was noticeably decreased in myocardial infarcted rat hearts and myocardial cells under hypoxic conditions, regulated other identified proteins, and was closely related to hypoxia-induced cell death.
    [Experimental and Molecular Medicine]

    Full Article

    Asiatic Acid Alleviates Ischemic Myocardial Injury in Mice by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism

    Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.
    [Acta Pharmacologica Sinica]

    Abstract

    Insulin-Like Growth Factor Binding Protein-1 Regulates HIF-1α-1α Degradation to Inhibit Apoptosis in Hypoxic Cardiomyocytes

    The authors demonstrated that hypoxia up-regulated insulin-like growth factor binding protein-1 (IGFBP-1) and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α was essential to IGFBP-1 function in cellular apoptosis.
    [Cell Death Discovery]

    Full Article

    Early Activation of the Cardiac CX3CL1/CX3CR1 Axis Delays β-Adrenergic-Induced Heart Failure

    Investigators characterized macrophages in hearts early infused with isoproterenol as compared to control and failing hearts and evaluated the role of upregulated CX3CL1 in cardiac remodeling.
    [Scientific Reports]

    Full Article

    FGF-2–Dependent Signaling Activated in Aged Human Skeletal Muscle Promotes Intramuscular Adipogenesis

    Using multiple screening assays upstream and downstream of miR-29a signaling, scientists located the secreted protein and adipogenic inhibitor SPARC to an fibroblast growth factor-2 (FGF-2) signaling pathway that was conserved between skeletal muscle cells from mice and humans and that was activated in skeletal muscle of aged mice and humans.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Malat-1-PRC2-EZH1 Interaction Supports Adaptive Oxidative Stress Dependent Epigenome Remodeling in Skeletal Myotubes

    Investigators studied terminally differentiated post-mitotic skeletal muscle cells in which oxidative stress induced the dynamic activation of PRC2-Ezh1 through embryonic ectoderm development shuttling to the nucleus and identified lncRNA Malat-1 as a necessary partner for PRC2-Ezh1-dependent response to oxidative stress.
    [Cell Death & Disease]

    Full Article

    CRISPR/Cas9/AAV9-Mediated In Vivo Editing Identifies MYC Regulation of 3D Genome in Skeletal Muscle Stem Cell

    Researchers demonstrated efficient editing of master transcription factor (TF) Myod1 locus using the CRISPR/Cas9/AAV9-sgRNA system in juvenile satellite cells (SCs). Application on two key TFs, MYC and BCL6, unveiled distinct functions in SC activation and muscle regeneration.
    [Stem Cell Reports]

    Full Article

    CRISPR/Cas9 Small Promoter Deletion in H19 lncRNA Is Associated with Altered Cell Morphology and Proliferation

    Scientists developed a non-cancer lineage with CRISPR-Cas9-mediated H19 knockdown and observed the changes in a cellular context. To edit the promoter region of H19, two RNA guides were designed, and the murine C2C12 myoblast cells were transfected.
    [Scientific Reports]

    Full Article

    Inhibition of MicroRNA-30a Alleviates Vascular Remodeling in Pulmonary Arterial Hypertension

    Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    A New Mfn-2 Related Synthetic Peptide Promotes Vascular Smooth Muscle Cell Apoptosis via Regulating the Mitochondrial Apoptotic Pathway by Inhibiting Akt Signaling

    The authors investigated whether mitofusin-2 (Mfn-2) gene related peptide enhanced apoptotic activities to inhibit vascular smooth muscle cell accumulation and neointimal hyperplasia in rats with carotid balloon injury.
    [Journal of Translational Medicine]

    Full Article

    Circ-Grm1 Promotes Pulmonary Artery Smooth Muscle Cell Proliferation and Migration via Suppression of GRM1 Expression by FUS

    Scientists determined the role and mechanism of circRNA‑glutamate metabotropic receptor 1 (circ-Grm1) in pulmonary artery smooth muscle cell proliferation and migration in hypoxic pulmonary hypertension.
    [International Journal of Molecular Medicine]

    Abstract

    Stay up-to-date with the latest stem cell research by listening to the Stem Cell Podcast!
    REVIEWS

    Minor Hypertrophic Cardiomyopathy Genes, Major Insights into the Genetics of Cardiomyopathies

    The authors appraise the complex contribution of the non-sarcomeric, hypertrophic cardiomyopathy-associated genes to cardiomyopathies across a range of variant classes, which provides insights into the genetic basis of cardiomyopathies, causal genes at genome-wide association studies loci and the application of clinical genetic testing.
    [Nature Reviews Cardiology]

    Abstract

    Deciphering the Chromatin Organization and Dynamics for Muscle Stem Cell Function

    Scientists focus on the regulatory network guiding the progression of muscle stem cells to differentiated progeny. They summarize recent findings regarding the mechanisms directing myogenic cell fate decision and differentiation, with a particular focus on three-dimensional chromosome architecture and long noncoding RNA-associated chromatin accessibility changes.
    [Current Opinion in Cell Biology]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    BridgeBio Pharma Receives FDA Fast Track Designation for Investigational Therapy for the Treatment of Limb-Girdle Muscular Dystrophy Type 2i (LGMD2i)

    BridgeBio Pharma, Inc. announced that the US FDA granted Fast Track designation for the investigation of BBP-418 as a treatment option for LGMD2i. 
    [BridgeBio Pharma, Inc.]

    Press Release

    FEATURED EVENT

    TEDD Annual Meeting: Cross-Industrial Applications of Organotypic Models

    October 14, 2021
    Wädenswil, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Musculoskeletal Tissue Regeneration

    University of Iowa – Iowa City, Iowa, United States

    Research Fellow – Cardiovascular Research

    Queen’s University Belfast – Belfast, Ireland

    Postdoctoral Associate – Cardiovascular Biology and Disease Modeling

    Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States

    Postdoctoral Positions – Organ Cross-Talk and Metabolic Disorders

    European Centre Study Diabetes – Strasbourg, France

    Postdoctoral Research Fellow – Cardiac and Endothelial Cell Function

    Stanford University – La Jolla, California, United States

    > See All Jobs

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