| Vol. 13.36 – 1 October, 2021 |
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| The authors showed that the pharmacokinetics and half-life of IL-2 could be substantially improved by orthogonally conjugating the cytokine to poly(ethylene glycol) (PEG) moieties via a copper-free click reaction through the incorporation of azide-bearing amino acids at defined sites. [Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers defined the heterogeneity of microglia and macrophage phenotypes during traumatic brain injury (TBI) in wild-type mice and Ccr2−/−` mice, which lacked macrophage influx following TBI and were resistant to brain damage. [Cell Reports] |
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| Lung dendritic cells (DCs) from tolerized mice induced a low Th2 response in vitro mirroring impact of tolerance in vivo. Wild type-Tol mice displayed a decrease in total, cDC1 and cDC2 subsets in the lung as compared to that in naive mice. [Mucosal Immunology] |
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| Investigators used the T cell transfer mouse model of colitis to identify small-molecule metabolites with altered abundance due to intestinal inflammation. [Science Signaling] |
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| Scientists reported that three splicing factors, SPF45, SR140 and CHERP formed a tight physical and functionally coherent complex that regulated a variety of alternative splicing events, frequently by repressing short exons flanked by suboptimal 3′ splice sites. [RNA] |
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| The authors showed the importance of immune tolerance for idiosyncratic drug toxicity (IDT) onset and determine whether it was susceptible to a common IDT, HLA-B*57:01-mediated abacavir-induced hypersensitivity, using CD4+ T cell-depleted programmed death-1 receptor-deficient HLA-B*57:01 transgenic mice [Communications Biology] |
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| Researchers investigated the ability of a recombinant BTN2A2-IgG2a Fc fusion protein to treat Collagen type II (CIA). They showed that administration of BTN2A2-Ig attenuatex established CIA, as compared with control Ig protein treatment. [Scientific Reports] |
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| SEC61G expression was analyzed using publicly available datasets. The association between SEC61G and disease prognosis was evaluated. [Cancer Medicine] |
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| The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line. [Molecular Medicine Reports] |
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| Scientists detail the role of the gut microbiome in chronic diseases and ways it can be modulated for the management or prevention of chronic conditions. [European Journal of Clinical Nutrition] |
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| Bio-Thera Solutions, Ltd. and Intract Pharma announced a global collaboration and licensing agreement that gives Bio-Thera access to Intract’s Soteria® and Phloral® drug delivery technologies to develop novel oral monoclonal antibody treatments for chronic gastrointestinal inflammatory diseases. [Bio-Thera Solutions, Ltd. (BusinessWire, Inc.)] |
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| TG Therapeutics, Inc. announced the submission of a Biologics License Application to the FDA requesting approval of ublituximab, the company’s investigational glycoengineered anti-CD20 monoclonal antibody, as a treatment for patients with relapsing forms of multiple sclerosis. [TG Therapeutics, Inc.] |
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| October 13 – 14, 2021 Virtual |
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| MD Anderson Cancer Center – Houston, Texas, United States |
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| Weill Cornell Medicine – New York, New York, United States |
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| University of Helsinki – Helsinki, Finland |
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| Scripps Research Florida – Jupiter, Florida, United States |
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| Karolinska Institutet – Stockholm, Sweden |
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