| Vol. 13.37 – 7 October, 2021 |
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| Investigators demonstrated that epithelial gland morphogenesis was induced by a local change from anisotropic to isotropic tension within the epithelial cell layer of developing human mammary gland organoids. [Nature Physics] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk. [Science Advances] |
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| Scientists observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer metastases. [Bone Research] |
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| Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression. [Cancer Research] |
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| Investigators showed that hypoxia-inducible factor 1α (HIF-1α) was required for NANOG-mediated breast CSC enrichment. [Cell Reports] |
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| Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer. [Oncogene] |
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| The authors identified RNA Binding Motif Single Stranded Interacting Protein 3 (RBMS3) as a novel and common effector of epithelial-to-mesenchymal transition (EMT), which could be a promising therapeutic target for TNBC treatment. [Oncogene] |
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| Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer. [Cell Death & Disease] |
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| Scientists identified nine cancer cell subclusters including CD44+/ALDH2+/ALDH6A1+ breast cancer stem cells, which had a copy-number variants profile similar to that of normal breast tissue. [Oncogenesis] |
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| Lung metastasis and endothelial function were analyzed together with blood nucleotides, plasma amino acids, nicotinamide metabolites, and vascular ectoenzymes of nucleotide catabolism. [Experimental & Molecular Medicine] |
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| Scientists found that melatonin synergized with doxorubicin to induce apoptosis of breast cancer cells by decreasing the expression of AMP-activated protein kinase α1 (AMPK α1), which acted as a critical survival factor for cancer cells. [Experimental & Molecular Medicine] |
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| The authors investigated pseudopodium-enriched atypical kinase 1 (PEAK1) expression in breast cancer and its role in breast cancer cells in vitro and in vivo and analyzed the relationship with clinicopathological status and chemotherapy resistance. [Clinical and Experimental Medicine] |
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| Investigators discuss the roles of ferroptosis-associated modulators glutathione, glutathione peroxidase 4, iron, nuclear factor erythroid-2 related factor-2, superoxide dismutases, lipoxygenase and coenzyme Q in breast cancer and provide evidence that ferroptosis inducers eliminate breast cancer cells. [Pharmacology & Therapeutics] |
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| Scientists provide an overview of interleukin-1 (IL-1)-mediated signal communication in breast cancer and discuss the potential of IL-1 as a therapeutic target especially for metastatic breast cancer and combination therapy and current problems. [Mediators of Inflammation] |
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| The authors discuss asymmetric cell division in breast/mammary stem cells and implications on further research, with focus on the role asymmetric cell division may play in breast cancer. [Cell Division] |
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| Telix Pharmaceuticals Limited announced that a first patient has been dosed in a Phase II study of TLX250-CDx in patients with TNBC. [Telix Pharmaceuticals] |
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| Gilead Sciences, Inc. announced that Health Canada has approved Trodelvy® for the treatment of adult patients with unresectable locally advanced or metastatic TNBC who have received two or more prior therapies, at least one of them for metastatic disease. [Gilead Sciences, Inc.] |
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| University of Windsor’s Munir Rahim has been awarded a $120,000 research grant through the Cancer Research Society for launching ground-breaking research that could lead to new treatments for breast cancer. [University of Windsor] |
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| November 1 – 3, 2021 Virtual |
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| City of Hope – Los Angeles, California, United States |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| Weill Cornell Medicine – New York, New York, United States |
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| Dalhousie University – Halifax, Nova Scotia, Canada |
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| Moores Cancer Center, UC San Diego – San Diego, California, United States |
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