 | | Vol. 13.37 – 7 October, 2021 |
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| Investigators demonstrated that epithelial gland morphogenesis was induced by a local change from anisotropic to isotropic tension within the epithelial cell layer of developing human mammary gland organoids.
[Nature Physics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk.
[Science Advances] |
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| Scientists observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer metastases.
[Bone Research] |
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| Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.
[Cancer Research] |
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| Investigators showed that hypoxia-inducible factor 1α (HIF-1α) was required for NANOG-mediated breast CSC enrichment.
[Cell Reports] |
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| Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.
[Oncogene] |
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| The authors identified RNA Binding Motif Single Stranded Interacting Protein 3 (RBMS3) as a novel and common effector of epithelial-to-mesenchymal transition (EMT), which could be a promising therapeutic target for TNBC treatment.
[Oncogene] |
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| Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.
[Cell Death & Disease] |
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| Scientists identified nine cancer cell subclusters including CD44+/ALDH2+/ALDH6A1+ breast cancer stem cells, which had a copy-number variants profile similar to that of normal breast tissue.
[Oncogenesis] |
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| Lung metastasis and endothelial function were analyzed together with blood nucleotides, plasma amino acids, nicotinamide metabolites, and vascular ectoenzymes of nucleotide catabolism.
[Experimental & Molecular Medicine] |
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| Scientists found that melatonin synergized with doxorubicin to induce apoptosis of breast cancer cells by decreasing the expression of AMP-activated protein kinase α1 (AMPK α1), which acted as a critical survival factor for cancer cells.
[Experimental & Molecular Medicine] |
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| The authors investigated pseudopodium-enriched atypical kinase 1 (PEAK1) expression in breast cancer and its role in breast cancer cells in vitro and in vivo and analyzed the relationship with clinicopathological status and chemotherapy resistance.
[Clinical and Experimental Medicine] |
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| Investigators discuss the roles of ferroptosis-associated modulators glutathione, glutathione peroxidase 4, iron, nuclear factor erythroid-2 related factor-2, superoxide dismutases, lipoxygenase and coenzyme Q in breast cancer and provide evidence that ferroptosis inducers eliminate breast cancer cells.
[Pharmacology & Therapeutics] |
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| Scientists provide an overview of interleukin-1 (IL-1)-mediated signal communication in breast cancer and discuss the potential of IL-1 as a therapeutic target especially for metastatic breast cancer and combination therapy and current problems.
[Mediators of Inflammation] |
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| The authors discuss asymmetric cell division in breast/mammary stem cells and implications on further research, with focus on the role asymmetric cell division may play in breast cancer.
[Cell Division] |
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| Telix Pharmaceuticals Limited announced that a first patient has been dosed in a Phase II study of TLX250-CDx in patients with TNBC.
[Telix Pharmaceuticals] |
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| Gilead Sciences, Inc. announced that Health Canada has approved Trodelvy® for the treatment of adult patients with unresectable locally advanced or metastatic TNBC who have received two or more prior therapies, at least one of them for metastatic disease.
[Gilead Sciences, Inc.] |
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| University of Windsor’s Munir Rahim has been awarded a $120,000 research grant through the Cancer Research Society for launching ground-breaking research that could lead to new treatments for breast cancer.
[University of Windsor] |
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| November 1 – 3, 2021
Virtual |
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| | City of Hope – Los Angeles, California, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| | Moores Cancer Center, UC San Diego – San Diego, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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