| Vol. 13.37 – 14 October, 2021 |
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| Scientists characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. They showed that maternal SARS-CoV-2 infection affected the neonatal immune system. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers examined bacterial infections in 20 patients who received umbilical cord blood–derived products marketed as stem cell treatment. [JAMA Network Open] |
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| The authors studied 57 patients in two centers who received myeloablative conditioning for cord blood transplant in Hurler syndrome, and reported a significant improvement in event-free survival with reduced incidence of graft failure and without any evidence of immune-mediated cytopenia in those patients that had received rituximab. [Bone Marrow Transplantation] |
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| Investigators proposed an optimized process using cord blood to generate minimally differentiated T cell products in terms of phenotype, function, gene expression, and metabolism, using peripheral blood-derived T cells cultured with IL-2 as a standard. [Cancer Gene Therapy] |
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| Human amniotic fluid stem cells could enhance cerebral vascular remodelling and have the potential to improve neurological function after stroke in diabetic rats. [Journal of Cellular and Molecular Medicine] |
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| Investigators analyzed RNA-sequence data to reveal expression profiles of circRNAs during osteogenesis of human umbilical cord MSCs, then elucidated the underlying mechanisms of action. [Scientific Reports] |
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| The authors evaluated the methylation pattern in cord blood in relation to pet ownership during pregnancy. [Genes & Immunity] |
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| Scientists discuss potential mechanisms of action for the therapeutic effects of MSC transplantation, experimental models that dissect tissue modulating function of MSCs, and approaches for identifying MSC effects in vivo by integrating biomarkers of disease and MSC activity. [Cell Stem Cell] |
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| Whitehead Institute Member Pulin Li has received a New Innovator Award from the National Institutes of Health (NIH). Li’s New Innovator Award will fund her investigations of how the different cell types in the body interact to form organs. [Whitehead Institute] |
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| Sutro Biopharma, Inc and BioNova Pharmaceuticals Limited announced an option agreement for BioNova to develop and commercialize STRO-001, a CD74-targeting Antibody-Drug Conjugate, for patients with hematologic cancers, in Greater China, including mainland China, Hong Kong, Macau and Taiwan. [Sutro Biopharma, Inc.] |
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| November 1 – 3, 2021 Virtual |
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| Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| The University of Kansas – Kansas City, Kansas, United States |
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| King Abdullah University of Science and Technology – Thuwal, Saudi Arabia |
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| University of Southern California – Los Angeles, California, United States |
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