Cord Blood News Volume 13.37 | Oct 14 2021

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    2021-10-14 | CBN 13.37


    Cord Blood News by STEMCELL Technologies
    Vol. 13.37 – 14 October, 2021
    TOP STORY

    The Legacy of Maternal SARS-CoV-2 Infection on the Immunology of the Neonate

    Scientists characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. They showed that maternal SARS-CoV-2 infection affected the neonatal immune system.
    [Nature Immunology]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Investigation of Bacterial Infections Among Patients Treated with Umbilical Cord Blood–Derived Products Marketed as Stem Cell Therapies

    Researchers examined bacterial infections in 20 patients who received umbilical cord blood–derived products marketed as stem cell treatment.
    [JAMA Network Open]

    Full Article

    B Cell Depletion Abrogates Immune Mediated Cytopenia and Rejection of Cord Blood Transplantation in Hurler Syndrome

    The authors studied 57 patients in two centers who received myeloablative conditioning for cord blood transplant in Hurler syndrome, and reported a significant improvement in event-free survival with reduced incidence of graft failure and without any evidence of immune-mediated cytopenia in those patients that had received rituximab.
    [Bone Marrow Transplantation]

    Full Article

    Homeostatic Cytokines Tune Naivety and Stemness of Cord Blood-Derived Transgenic T Cells

    Investigators proposed an optimized process using cord blood to generate minimally differentiated T cell products in terms of phenotype, function, gene expression, and metabolism, using peripheral blood-derived T cells cultured with IL-2 as a standard.
    [Cancer Gene Therapy]

    Abstract

    Human Amniotic Fluid Stem Cells Can Improve Cerebral Vascular Remodelling and Neurological Function after Focal Cerebral Ischaemia in Diabetic Rats

    Human amniotic fluid stem cells could enhance cerebral vascular remodelling and have the potential to improve neurological function after stroke in diabetic rats.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Transcriptomic Profiling and Functional Prediction Reveal Aberrant Expression of Circular RNAs during Osteogenic Differentiation in Human Umbilical Cord Mesenchymal Stromal Cells

    Investigators analyzed RNA-sequence data to reveal expression profiles of circRNAs during osteogenesis of human umbilical cord MSCs, then elucidated the underlying mechanisms of action.
    [Scientific Reports]

    Full Article

    Pet Ownership in Pregnancy and Methylation Pattern in Cord Blood

    The authors evaluated the methylation pattern in cord blood in relation to pet ownership during pregnancy.
    [Genes & Immunity]

    Full Article

    How to prioritize and manage your research projects
    REVIEWS

    Mesenchymal Stromal Cells: Putative Microenvironmental Modulators Become Cell Therapy

    Scientists discuss potential mechanisms of action for the therapeutic effects of MSC transplantation, experimental models that dissect tissue modulating function of MSCs, and approaches for identifying MSC effects in vivo by integrating biomarkers of disease and MSC activity.
    [Cell Stem Cell]

    Abstract

    INDUSTRY AND POLICY NEWS

    Whitehead Institute Member Pulin Li Receives NIH New Innovator Award

    Whitehead Institute Member Pulin Li has received a New Innovator Award from the National Institutes of Health (NIH). Li’s New Innovator Award will fund her investigations of how the different cell types in the body interact to form organs.
    [Whitehead Institute]

    Press Release

    Sutro Biopharma and BioNova Pharmaceuticals Enter into Collaboration for STRO-001 in Greater China

    Sutro Biopharma, Inc and BioNova Pharmaceuticals Limited announced an option agreement for BioNova to develop and commercialize STRO-001, a CD74-targeting Antibody-Drug Conjugate, for patients with hematologic cancers, in Greater China, including mainland China, Hong Kong, Macau and Taiwan.
    [Sutro Biopharma, Inc.]

    Press Release

    FEATURED EVENT

    Biological Assemblies: Phase Transitions

    November 1 – 3, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Advanced Research Assistant – Human Cell Atlas

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Position – Computational Biology of Sarcomas

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Faculty Position – Hematopoiesis and Hematologic Malignancies

    The University of Kansas – Kansas City, Kansas, United States

    Postdoctoral Position – Stem Cells and Disease Modeling

    King Abdullah University of Science and Technology – Thuwal, Saudi Arabia

    Research Associate – Organogenesis, Stem Cells, and Regenerative Medicine

    University of Southern California – Los Angeles, California, United States

    > See All Jobs

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