| Vol. 15.41 – 20 October, 2021 |
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| Gastrointestinal motility disorders occur frequently in patients with ciliopathy, but the underlying genetic link is unclear. Mechanistically, Kif7 inhibited Gli2 in enteric neural crest cells, where Gli2 positively regulated the expression of Ezh2 by inhibiting the miR124-mediated suppression. [Science Advances] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that at activated glutamatergic post-synaptic sites, both the YTHDF1 and YTHDF3 reader and the ALKBH5 eraser proteins increased in co-localization to m6A-modified RNAs; but only the readers showed high co-localization to modified RNAs during late-stage plasticity. [Molecular Psychiatry] |
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| Scientists identified PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docked onto Pol II CTD through its SPOC domain. Key neuronal genes were aberrantly expressed in Phf3 knock-out mouse embryonic stem cells, resulting in impaired neuronal differentiation. [Nature Communications] |
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| The authors established a pipeline for characterizing an allelic series of dystonia-specific mutations. They used this strategy to investigate the molecular consequences of genetic variation in THAP1, which encoded a transcription factor linked to neural differentiation. [American Journal of Human Genetics] |
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| Investigators showed the nicotinamide analog 3-acetylpyridine, was converted to 3-APMN, which activated SARM1 and induced SARM1-dependent NAD+ depletion, axon degeneration, and neuronal death. [Cell Reports] |
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| Scientists found that GABABR phosphorylated the kinase JNK downstream of activation of the small guanosine triphosphatases RhoA and Rac1 in primary mouse neurons. [Science Signaling] |
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| Investigators used the YAC128 murine model of Huntington’s disease to examine the effects of mutant huntingtin on mitochondrial parameters related to aging in brain and skeletal muscle. [npj Aging and Mechanisms of Disease] |
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| Scientists provided an integrative analysis of cellular metabolism during the early stages of amyloid-β accumulation in the cerebral cortex and hippocampus of the 5xFAD mouse model of Alzheimer’s disease. [Cell Death & Disease] |
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| Investigators found that bilobalide inhibited Aβ-induced and STAT3-dependent expression of TNF-α, IL-1β, and IL-6 in primary astrocyte culture. [Translational Psychiatry] |
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| The identity of a glycinergic synapse was maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptured glycine back to presynaptic terminals to preserve vesicular glycine content. The authors identified the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity. [Communications Biology] |
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| Researchers used machine learning techniques to characterize and predict the developing spontaneous activity in mouse cortical neurons on microelectrode arrays during the first three weeks in vitro. [Scientific Reports] |
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| The genes mutated in primary hereditary microcephaly are ubiquitously expressed in proliferating cells, but under normal conditions are selectively required during brain development, in neural progenitors. [Cell Death & Disease] |
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| Inhibikase Therapeutics, Inc. announced dosing of the first Parkinson’s patient in its Phase Ib clinical trial of IkT-148009, an Abelson Tyrosine Kinase, or c-Abl, inhibitor for the treatment of Parkinson’s disease. [Inhibikase Therapeutics, Inc.] |
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| October 26 – 28, 2021 Virtual |
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| University of Calgary – Calgary, Alberta, Canada |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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| Center for Molecular and Behavioral Neuroscience – Newark, New Jersey, United States |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| University of Southern California – Los Angeles, California, United States |
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