| Vol. 6.37 – 1 November, 2021 |
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| Using smooth muscle cells (SMCs), mouse models, and human atherosclerosis specimens, scientists found that focal adhesion kinase (FAK) activation elicited SMC dedifferentiation by stabilizing DNA methyltransferase 3A. [Circulation Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified that the molecular machinery for membrane protein synthesis occurs throughout the cardiac myocyte, and enabled distributed synthesis of membrane proteins within sub-cellular niches where the synthesized protein functions using local mRNA pools trafficked, in part, by microtubules. [Basic Research in Cardiology] |
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| RNA sequencing was conducted to investigate the exosomal long non-coding RNA (lncRNA) transcriptome from myocardial infarction (MI) patients and identified 65 differentially expressed lncRNAs between the MI and control groups. [Cell Death & Disease] |
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| The effects of beta-cardiotoxin on isolated cardiac myocyte functions, calcium homeostasis, the phosphorylation level of targeted proteins, and the myofibrillar ATPase activity were studied. [Scientific Reports] |
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| The authors revealed that programmed cell death 5 deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53. [International Journal of Cardiology] |
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| Scientists investigated the effects of four mouse genotypes with increasingly severe RyR1 leak in skeletal muscle fibers. [Science Advances] |
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| Researchers developed a method to detect and quantify single molecule RNA localization patterns in skeletal myofibers, and uncovered a critical role for directed transport of RNPs in muscle. [Nature Communications] |
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| Resolvin-D2 directly targeted myogenic cells and promoted their differentiation and the expansion of the pool of myogenic progenitor cells leading to increased myogenesis. [Nature Communications] |
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| A dystrophin-deficient myoblast cell line established from the skeletal muscle of a dystrophic mouse was used as a model. Dfd13 and C2C12 myoblasts were cultured in low mitogen conditions for ten days to induce differentiation. [Cell Communication and Signaling] |
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| Investigators developed a novel fully-automated image segmentation method based on neutrosophic set algorithms to analyze whole skeletal muscle cross sections in exercise-induced regenerating myofibers, referred as MyoView, designed to obtain accurate fiber size and distribution measurements. [Scientific Reports] |
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| The authors suggested that HIF-1α, as an upstream regulator, promoted the expression of Connexin 43 (Cx43), and the HIF-1α/Cx43 axis regulated the proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension. [Journal of Cellular and Molecular Medicine] |
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| Researchers suggested that miR548ai, a rarely known microRNA, may have provided a molecular target for protection against smooth muscle cell/exosome-induced endothelial cell dysfunction. [Cell Death Discovery] |
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| Scientists explored the detailed role and mechanism of circRNA LIF receptor subunit alpha in human umbilical artery smooth muscle cells. [Metabolic Brain Disease] |
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| The authors detail each individual process involved in cell death, as well as highlight how they come together to produce various cardiac pathologies. [Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
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| Investigators summarize current knowledge about vascular smooth muscle cells (vSMCs) functions within the aortic wall and give an overview of how vSMC functions are dysregulated in aortic aneurysms and aortic dissections pathogenesis, organized per anatomical location. [European Journal of Clinical Investigation] |
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| CANbridge Pharmaceuticals, Inc. announced that it has entered into a two-year sponsored research agreement with the University of Washington School of Medicine, in Seattle, Washington, for gene therapy research in Duchenne muscular dystrophy, a rare neuromuscular disease. [CANbridge Pharmaceuticals, Inc.] |
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| November 10 – 19, 2021 Virtual |
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| Saint Louis University – St. Louis, Missouri, United States |
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| Columbia University – New York, New York, United States |
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| Sarepta Therapeutics Inc. – Columbus, Ohio, United States |
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| Northwestern University – Chicago, Illinois, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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