Muscle Cell News Volume 6.37 | Nov 1 2021

May 12, 2022

2021-11-01 | MUSCN 6.37

Muscle Cell News by STEMCELL Technologies

Vol. 6.37 – 1 November, 2021

TOP STORY

FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes

Using smooth muscle cells (SMCs), mouse models, and human atherosclerosis specimens, scientists found that focal adhesion kinase (FAK) activation elicited SMC dedifferentiation by stabilizing DNA methyltransferase 3A.
[Circulation Research]

Abstract

Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human).

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Distributed Synthesis of Sarcolemmal and Sarcoplasmic Reticulum Membrane Proteins in Cardiac Myocytes

Researchers identified that the molecular machinery for membrane protein synthesis occurs throughout the cardiac myocyte, and enabled distributed synthesis of membrane proteins within sub-cellular niches where the synthesized protein functions using local mRNA pools trafficked, in part, by microtubules.
[Basic Research in Cardiology]

Full Article

Loss of Exosomal lncRNA HCG15 Prevents Acute Myocardial Ischemic Injury through the NF-κB/p65 and p38 Pathways

RNA sequencing was conducted to investigate the exosomal long non-coding RNA (lncRNA) transcriptome from myocardial infarction (MI) patients and identified 65 differentially expressed lncRNAs between the MI and control groups.
[Cell Death & Disease]

Full Article

Negative Inotropic Mechanisms of β-Cardiotoxin in Cardiomyocytes by Depression of Myofilament ATPase Activity without Activation of the Classical β-Adrenergic Pathway

The effects of beta-cardiotoxin on isolated cardiac myocyte functions, calcium homeostasis, the phosphorylation level of targeted proteins, and the myofibrillar ATPase activity were studied.
[Scientific Reports]

Full Article

Muscle-Specific Programmed Cell Death 5 Deletion Attenuates Cardiac Aging

The authors revealed that programmed cell death 5 deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.
[International Journal of Cardiology]

Abstract

SKELETAL MUSCLE CELLS

Ryanodine Receptor Leak Triggers Fiber Ca²⁺ Redistribution to Preserve Force and Elevate Basal Metabolism in Skeletal Muscle

Scientists investigated the effects of four mouse genotypes with increasingly severe RyR1 leak in skeletal muscle fibers.
[Science Advances]

Full Article

Microtubule-Based Transport Is Essential to Distribute RNA and Nascent Protein in Skeletal Muscle

Researchers developed a method to detect and quantify single molecule RNA localization patterns in skeletal myofibers, and uncovered a critical role for directed transport of RNPs in muscle.
[Nature Communications]

Full Article

Resolvin-D2 Targets Myogenic Cells and Improves Muscle Regeneration in Duchenne Muscular Dystrophy

Resolvin-D2 directly targeted myogenic cells and promoted their differentiation and the expansion of the pool of myogenic progenitor cells leading to increased myogenesis.
[Nature Communications]

Full Article

Perturbation of PI3K/Akt Signaling Affected Autophagy Modulation in Dystrophin-Deficient Myoblasts

A dystrophin-deficient myoblast cell line established from the skeletal muscle of a dystrophic mouse was used as a model. Dfd13 and C2C12 myoblasts were cultured in low mitogen conditions for ten days to induce differentiation.
[Cell Communication and Signaling]

Full Article

Automated Image Segmentation Method to Analyze Skeletal Muscle Cross Section in Exercise-Induced Regenerating Myofibers

Investigators developed a novel fully-automated image segmentation method based on neutrosophic set algorithms to analyze whole skeletal muscle cross sections in exercise-induced regenerating myofibers, referred as MyoView, designed to obtain accurate fiber size and distribution measurements.
[Scientific Reports]

Full Article

SMOOTH MUSCLE CELLS

HIF-1α Promotes the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via Activation of Cx43

The authors suggested that HIF-1α, as an upstream regulator, promoted the expression of Connexin 43 (Cx43), and the HIF-1α/Cx43 axis regulated the proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
[Journal of Cellular and Molecular Medicine]

Full Article

miR548ai Antagonism Attenuates Exosome-Induced Endothelial Cell Dysfunction

Researchers suggested that miR548ai, a rarely known microRNA, may have provided a molecular target for protection against smooth muscle cell/exosome-induced endothelial cell dysfunction.
[Cell Death Discovery]

Full Article

Circular RNA circLIFR Regulates the Proliferation, Migration, Invasion and Apoptosis of Human Vascular Smooth Muscle Cells via the miR-1299/KDR Axis

Scientists explored the detailed role and mechanism of circRNA LIF receptor subunit alpha in human umbilical artery smooth muscle cells.
[Metabolic Brain Disease]

Abstract

Explore Antibodies for Epithelial Cell Markers

REVIEWS

The Molecular Mosaic of Regulated Cell Death in the Cardiovascular System

The authors detail each individual process involved in cell death, as well as highlight how they come together to produce various cardiac pathologies.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]

Abstract

The Role of Vascular Smooth Muscle Cells in the Development of Aortic Aneurysms and Dissections

Investigators summarize current knowledge about vascular smooth muscle cells (vSMCs) functions within the aortic wall and give an overview of how vSMC functions are dysregulated in aortic aneurysms and aortic dissections pathogenesis, organized per anatomical location.
[European Journal of Clinical Investigation]

Abstract Full Article

INDUSTRY AND POLICY NEWS

CANbridge Pharmaceuticals Enters into Duchenne Muscular Dystrophy Gene Therapy Research Agreement with University of Washington School of Medicine

CANbridge Pharmaceuticals, Inc. announced that it has entered into a two-year sponsored research agreement with the University of Washington School of Medicine, in Seattle, Washington, for gene therapy research in Duchenne muscular dystrophy, a rare neuromuscular disease.
[CANbridge Pharmaceuticals, Inc.]

Press Release

FEATURED EVENT

FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes

Distributed Synthesis of Sarcolemmal and Sarcoplasmic Reticulum Membrane Proteins in Cardiac Myocytes

Loss of Exosomal lncRNA HCG15 Prevents Acute Myocardial Ischemic Injury through the NF-κB/p65 and p38 Pathways

Negative Inotropic Mechanisms of β-Cardiotoxin in Cardiomyocytes by Depression of Myofilament ATPase Activity without Activation of the Classical β-Adrenergic Pathway

Muscle-Specific Programmed Cell Death 5 Deletion Attenuates Cardiac Aging

Ryanodine Receptor Leak Triggers Fiber Ca²⁺ Redistribution to Preserve Force and Elevate Basal Metabolism in Skeletal Muscle

Microtubule-Based Transport Is Essential to Distribute RNA and Nascent Protein in Skeletal Muscle

Resolvin-D2 Targets Myogenic Cells and Improves Muscle Regeneration in Duchenne Muscular Dystrophy

Perturbation of PI3K/Akt Signaling Affected Autophagy Modulation in Dystrophin-Deficient Myoblasts

Automated Image Segmentation Method to Analyze Skeletal Muscle Cross Section in Exercise-Induced Regenerating Myofibers

HIF-1α Promotes the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via Activation of Cx43

miR548ai Antagonism Attenuates Exosome-Induced Endothelial Cell Dysfunction

Circular RNA circLIFR Regulates the Proliferation, Migration, Invasion and Apoptosis of Human Vascular Smooth Muscle Cells via the miR-1299/KDR Axis

The Molecular Mosaic of Regulated Cell Death in the Cardiovascular System

The Role of Vascular Smooth Muscle Cells in the Development of Aortic Aneurysms and Dissections

CANbridge Pharmaceuticals Enters into Duchenne Muscular Dystrophy Gene Therapy Research Agreement with University of Washington School of Medicine

American College of Toxicology Annual Meeting

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Vice President – Medical Affairs and Dean of the School of Medicine

Scientist – iPSC Derived Cardiac Tissues

Research Associate – Histology & Morphometrics

Postdoctoral Research Fellow – iPSC Reprogramming

Research Assistant – Skeletal Muscle

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