| Vol. 12.44 – 9 November, 2021 |
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| Cancer-associated fibroblasts were isolated from metastases and subjected to DNA methylation and whole transcriptomic RNA sequencing analysis. [Journal of Hematology & Oncology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| | Investigators explored the effects of dipeptidyl peptidase inhibition on the tumor immune landscape using RNAseq, immunohistochemistry, cytokine evaluation and flow cytometry. [Journal For Immunotherapy of Cancer] |
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| To isolate the function of the serine-dependent regulation of pyruvate dehydrogenase complex, scientists engineered MiaPaca2 cells to express PDHA1 protein with either intact serines at positions 232, 293, and 300 or all the combinations of non-phosphorylatable alanine substitution mutations. [Cancer & Metabolism] |
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| Researchers examined the proliferation and drug resistance effect of ADP-ribosylation factor like-4c (Arl4c) on pancreatic cancer cells. They explored the contribution of Arl4c high expression in pancreatic stellate cell activation. [iScience] |
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| The authors identified the possible derivation of gastroenteropancreatic neuroendocrine tumors using genome-wide analyses to distinguish small intestinal neuroendocrine tumours, specifically duodenal gastrinomas from pancreatic neuroendocrine tumors. [BMJ Open Gastroenterology] |
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| Scientists identified the expression of miR-361-5p, IL-17A, nuclear factor IA, and hes family bHLH transcription factor 1 in serum samples collected from patients with acute pancreatitis, caerulein-induced mice, and a Th17 cell model. [Journal of Medicinal Chemistry] |
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| Researchers demonstrated a direct effect of cholecystokinin to reduce cytokine-mediated apoptosis in a β-cell line and in isolated mouse islets in a receptor-dependent manner. [Translational Research] |
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| The authors examined the role of Bcl2-associated athanogene (BAG3) to activate human fibroblasts in releasing cytokines capable of supporting tumor progression. [Journal of Cellular Biochemistry] |
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| Scientists showed that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffered from overt obesity, glucose intolerance, and hepatic steatosis. [Scientific Reports] |
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| Semaglutide increased islet cell proliferation and recovered islet size and alpha- and beta-cell masses. [Biochimie] |
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| Scientists discuss the implications of a heterogenous insulin secretory granules (ISG) population in β-cells and highlight the need for more understanding into how unique ISG populations may be targeted in anti-diabetic therapies. [Biochemical Pharmacology] |
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| The author review recent study updates of sphingosine 1 phosphate (S1P), summarizing its effects on type 2 diabetes mellitus with respect to pathogenesis, promoting β cell proliferation and inhibiting apoptosis, reducing insulin resistance, protecting the liver and pancreas from lipotoxic damage, improving intestinal incretin effects, lowering basal glucagon levels, etc. [Journal of Diabetes Research] |
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| Sanofi and Roche Diabetes Care France have joined forces regarding the smart device Mallya® for SoloStar developed by Biocorp specializing in the development and manufacture of medical devices and injectable drug delivery systems. [Sanofi and Roche Diabetes Care France (GlobeNewswire, Inc.)] |
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| October 13 – 15, 2021 Virtual |
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| University of Southern Denmark – Odense M, Denmark |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Harvard Medical School – Boston, Massachusettes, United States |
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| University of California Los Angeles – Los Angeles, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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