Pancreatic Cell News Volume 12.44 | Nov 09 2021

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    2021-11-09 | PACN 12.44


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.44 – 9 November, 2021
    TOP STORY

    Cancer-Associated Fibroblast Heterogeneity Is Associated with Organ-Specific Metastasis in Pancreatic Ductal Adenocarcinoma

    Cancer-associated fibroblasts were isolated from metastases and subjected to DNA methylation and whole transcriptomic RNA sequencing analysis.
    [Journal of Hematology & Oncology]

    Full Article

    Dr. Sylvia Boj discusses how organoids are revolutionizing drug screening for cystic fibrosis in this webinar
    PUBLICATIONSRanked by the impact factor of the journal

    DPP Inhibition Alters the CXCR3 Axis and Enhances NK and CD8+ T Cell Infiltration to Improve Anti-PD1 Efficacy in Murine Models of Pancreatic Ductal Adenocarcinoma

    Investigators explored the effects of dipeptidyl peptidase inhibition on the tumor immune landscape using RNAseq, immunohistochemistry, cytokine evaluation and flow cytometry.
    [Journal For Immunotherapy of Cancer]

    Full Article

    Dynamic Regulation of Mitochondrial Pyruvate Metabolism Is Necessary for Orthotopic Pancreatic Tumor Growth

    To isolate the function of the serine-dependent regulation of pyruvate dehydrogenase complex, scientists engineered MiaPaca2 cells to express PDHA1 protein with either intact serines at positions 232, 293, and 300 or all the combinations of non-phosphorylatable alanine substitution mutations.
    [Cancer & Metabolism]

    Full Article

    Arl4c Promotes the Growth and Drug Resistance of Pancreatic Cancer by Regulating Tumor-Stromal Interactions

    Researchers examined the proliferation and drug resistance effect of ADP-ribosylation factor like-4c (Arl4c) on pancreatic cancer cells. They explored the contribution of Arl4c high expression in pancreatic stellate cell activation.
    [iScience]

    Abstract
    Full ArticleGraphical Abstract

    Genome Analysis Identifies Differences in the Transcriptional Targets of Duodenal versus Pancreatic Neuroendocrine Tumors

    The authors identified the possible derivation of gastroenteropancreatic neuroendocrine tumors using genome-wide analyses to distinguish small intestinal neuroendocrine tumours, specifically duodenal gastrinomas from pancreatic neuroendocrine tumors.
    [BMJ Open Gastroenterology]

    Abstract

    MicroRNA-361-5p Aggravates Acute Pancreatitis by Promoting Interleukin-17A Secretion via Impairment of Nuclear Factor IA-Dependent Hes1 Downregulation

    Scientists identified the expression of miR-361-5p, IL-17A, nuclear factor IA, and hes family bHLH transcription factor 1 in serum samples collected from patients with acute pancreatitis, caerulein-induced mice, and a Th17 cell model.
    [Journal of Medicinal Chemistry]

    AbstractGraphical Abstract

    Cholecystokinin Attenuates β-Cell Apoptosis in both Mouse and Human Islets

    Researchers demonstrated a direct effect of cholecystokinin to reduce cytokine-mediated apoptosis in a β-cell line and in isolated mouse islets in a receptor-dependent manner.
    [Translational Research]

    Abstract

    BAG3 Induces Fibroblasts to Release Key Cytokines Involved in Pancreatic Cell Migration

    The authors examined the role of Bcl2-associated athanogene (BAG3) to activate human fibroblasts in releasing cytokines capable of supporting tumor progression.
    [Journal of Cellular Biochemistry]

    Full Article

    Adipose MDM2 Regulates Systemic Insulin Sensitivity

    Scientists showed that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffered from overt obesity, glucose intolerance, and hepatic steatosis.
    [Scientific Reports]

    Full Article

    Pancreatic Islet Cells Disarray, Apoptosis, and Proliferation in Obese Mice. The Role of Semaglutide Treatment

    Semaglutide increased islet cell proliferation and recovered islet size and alpha- and beta-cell masses.
    [Biochimie]

    Abstract

    Scientific resources to support your organoids research. Learn More!
    REVIEWS

    Targeting the Insulin Granule for Modulation of Insulin Exocytosis

    Scientists discuss the implications of a heterogenous insulin secretory granules (ISG) population in β-cells and highlight the need for more understanding into how unique ISG populations may be targeted in anti-diabetic therapies.
    [Biochemical Pharmacology]

    Full ArticleGraphical Abstract

    S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes

    The author review recent study updates of sphingosine 1 phosphate (S1P), summarizing its effects on type 2 diabetes mellitus with respect to pathogenesis, promoting β cell proliferation and inhibiting apoptosis, reducing insulin resistance, protecting the liver and pancreas from lipotoxic damage, improving intestinal incretin effects, lowering basal glucagon levels, etc.
    [Journal of Diabetes Research]

    Full Article

    INDUSTRY AND POLICY NEWS

    Sanofi and Roche Diabetes Care France Join Forces to Improve the Management of Diabetes with the Connected Device Mallya® for Solostar®

    Sanofi and Roche Diabetes Care France have joined forces regarding the smart device Mallya® for SoloStar developed by Biocorp specializing in the development and manufacture of medical devices and injectable drug delivery systems.
    [Sanofi and Roche Diabetes Care France (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    Microbiome Interactions in Health and Disease

    October 13 – 15, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Endocrinology and Cancer Research

    University of Southern Denmark – Odense M, Denmark

    Research Associate – Obesity and Metabolic Disorders

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Type II Diabetes

    Harvard Medical School – Boston, Massachusettes, United States

    Postdoctoral Position – Pancreatic Adenocarcinoma

    University of California Los Angeles – Los Angeles, California, United States

    Postdoctoral Associate – Neurobiology of Obesity and Diabetes

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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