| Vol. 7.40 – 15 November, 2021 |
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| Researchers found that the cytokine oncostatin M was highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch. [Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus. [Oxidative Medicine and Cellular Longevity] |
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| Researchers showed that curcumin-bound silver nanoparticles exhibited low cytotoxicity and enhanced proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. [Scientific Reports] |
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| Investigators found that oxymatrine promoted hypertrophic scar repair by decreasing human scar fibroblast viability and collagen, and induced apoptosis via autophagy inhibition. [International Wound Journal] |
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| The authors used global gene expression and genome-wide DNA methylation analyses of dermal fibroblasts from a unique cohort of twins discordant for systemic sclerosis to identify molecular features of this pathology. [Annals of the Rheumatic Diseases] |
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| The role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in tumor growth was assessed in xenotransplantation experiments followed by immunohistochemistry analysis of the tumors. [Journal of Biomedical Science] |
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| Nanocomposite hydrogel effluents were cytocompatible with human dermal fibroblasts and demonstrated pH-dependent drug release and promising therapeutic efficacy against A431 and G361 skin cancer cells in vitro. [Journal of Materials Chemistry B] |
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| Logical model simulations describing the function of cytokine and eicosanoid signaling networks combined with experimental data suggest that T-helper (Th) 17 cytokines stimulate proinflammatory cytokine expression in psoriatic keratinocytes. [iScience] |
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| Researchers suggested that upregulation of miR-122 induced apoptosis, potentially via the repression of insulin-like growth factor 1 receptor (IGF1R) in human dermal papilla cells of androgenetic alopecia. [Cell Biology International] |
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| This is the first systematic review to characterize publicly available skin image datasets, highlighting limited applicability to real-life clinical settings and restricted population representation, precluding generalizability. [Lancet] |
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| The authors propose a novel framework to assess atopic dermatitis (AD) based on literature review and clinical experience. Rather than placing focus on any single specific aspect of AD, DESCRIBE-AD allows for a comprehensive approach to the assessment and clinical management of AD. [Journal of the American Academy of Dermatology] |
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| Highlight Therapeutics, Inc. announced positive preliminary results of a Phase II study of intratumoral administration of BO-112 with pembrolizumab in patients with advanced melanoma whose disease had progressed on first-line anti-PD1-based therapy. [Highlight Therapeutics, Inc.] |
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| Horizon Therapeutics plc announced the first patient has enrolled in a Phase IIb pivotal trial to evaluate its development-stage medicine HZN-825 to treat people with diffuse cutaneous systemic sclerosis, a subset of systemic sclerosis. [Horizon Therapeutics plc] |
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| December 1 – 10, 2021 Virtual |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Columbia University Medical Center – New York, New York, United States |
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| Novo Nordisk – Indianapolis, Indiana, United States |
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