| Vol. 16.03 – 26 January, 2022 |
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| Researchers showed that frontotemporal dementia mutations impaired bioenergetics and markedly diminished Tau’s interaction with mitochondria proteins, which were downregulated in Alzheimer’s disease brains of multiple cohorts and correlated with disease severity. [Cell] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that depletion of Fbl, an rRNA methyltransferase, reduced translation of both Ezh2 methyltransferase and Kdm6b demethylase of H3 trimethylation in Lys27 and delayed the progression of the neural stem cell state. [Nature Communications] |
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| The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells. [Nature Communications] |
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| Investigators compared single-cell RNA-sequencing data of human midbrain organoids to the developing human embryonic midbrain. [American Journal of Human Genetics] |
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| Researchers examined the dynamics of dopamine release and downstream signaling during multiple salient events occurring within tens of seconds and performed real-time tracking and manipulation of cyclic adenosine monophosphate (cAMP) in basal amygdala neurons in vitro and in vivo. [Cell Reports] |
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| Scientists showed that P2X7A and B receptor isoform levels were inversely modulated during the post-irradiation recovery phase in glioblastoma cells. [Cell Death & Disease] |
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| The authors indicated that the IONIS 486178 antisense oligonucleotide (ASO) targeted mutant DMPK mRNAs in the brain and strongly supported the feasibility of a therapy for dystrophia myotonica type 1 patients based on the intrathecal injection of an ASO. [Gene Therapy] |
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| Researchers investigated the physiological mechanisms by which extracellular vesicle-encapsulated miR-181a–2–3p derived from mesenchymal stem cells might mediate oxidative stress in Parkinson’s disease. [Cell Death Discovery] |
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| C57BL/6 mice were used to isolate and identify CD133+GFAP+CD117+Sca1+ cells in the hippocampal dentate gyrus region of the mouse brain as a novel neural stem cell population, in terms of cell phenotype, self-renewal capacity, and differentiation capability. [Molecular and Cellular Biochemistry] |
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| The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia. [Current Stem Cell Research & Therapy] |
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| Scientists review new types of clinical trials to evaluate whether cytoprotective drugs can slow infarct growth prior to reperfusion and/or ameliorate the consequences of reperfusion, such as hemorrhagic transformation. [New England Journal of Medicine] |
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| Glioblastoma is the most lethal primary brain tumor with a dismal prognosis despite maximal therapy. The development of new therapies in this aggressive type of tumors remains highly challenging partially due to the cold tumor immune environment. [Genes & Immunity] |
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| NTT Research, Inc. announced that it has entered a joint research agreement with scientists at Harvard University to study animal neuro-responses with the hope of informing future artificial intelligence systems. [NTT Research, Inc.] |
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| Athira Pharma, Inc. announced that patient dosing has begun in SHAPE, a Phase II clinical trial of ATH-1017 for the treatment of Parkinson’s disease dementia and dementia with lewy bodies. [Athira Pharma, Inc.] |
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| March 9 – 11, 2022 Melbourne, Victoria, Australia |
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| Hector Institute for Translational Brain Research – Mannheim, Germany |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Free University of Berlin – Berlin, Germany |
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| Queen Mary University of London – London, England, United Kingdom |
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| The Hong Kong University of Science and Technology – Guangzhou, China |
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