Neural Cell News Volume 16.03 | Jan 26 2022

May 12, 2022

2022-01-26 | NCN 16.03

Neural Cell News by STEMCELL Technologies

Vol. 16.03 – 26 January, 2022

TOP STORY

Tau Interactome Maps Synaptic and Mitochondrial Processes Associated with Neurodegeneration

Researchers showed that frontotemporal dementia mutations impaired bioenergetics and markedly diminished Tau’s interaction with mitochondria proteins, which were downregulated in Alzheimer’s disease brains of multiple cohorts and correlated with disease severity.
[Cell]

Full Article Press Release Graphical Abstract

Survey results on the insights and hurdles of CRISPR genome editing.

PUBLICATIONSRanked by the impact factor of the journal

Selective Translation of Epigenetic Modifiers Affects the Temporal Pattern and Differentiation of Neural Stem Cells

Scientists found that depletion of Fbl, an rRNA methyltransferase, reduced translation of both Ezh2 methyltransferase and Kdm6b demethylase of H3 trimethylation in Lys27 and delayed the progression of the neural stem cell state.
[Nature Communications]

Full Article

Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids

The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.
[Nature Communications]

Full Article

Midbrain Organoids Mimic Early Embryonic Neurodevelopment and Recapitulate LRRK2-p.Gly2019Ser-Associated Gene Expression

Investigators compared single-cell RNA-sequencing data of human midbrain organoids to the developing human embryonic midbrain.
[American Journal of Human Genetics]

Full Article Graphical Abstract

History-Dependent Dopamine Release Increases cAMP Levels in Most Basal Amygdala Glutamatergic Neurons to Control Learning

Researchers examined the dynamics of dopamine release and downstream signaling during multiple salient events occurring within tens of seconds and performed real-time tracking and manipulation of cyclic adenosine monophosphate (cAMP) in basal amygdala neurons in vitro and in vivo.
[Cell Reports]

Full Article Graphical Abstract

Irradiation Causes Senescence, ATP Release, and P2X7 Receptor Isoform Switch in Glioblastoma

Scientists showed that P2X7A and B receptor isoform levels were inversely modulated during the post-irradiation recovery phase in glioblastoma cells.
[Cell Death & Disease]

Full Article

Antisense Oligonucleotides as a Potential Treatment for Brain Deficits Observed in Myotonic Dystrophy Type 1

The authors indicated that the IONIS 486178 antisense oligonucleotide (ASO) targeted mutant DMPK mRNAs in the brain and strongly supported the feasibility of a therapy for dystrophia myotonica type 1 patients based on the intrathecal injection of an ASO.
[Gene Therapy]

Full Article Graphical Abstract

MicroRNA-181a–2–3p Shuttled by Mesenchymal Stem Cell-Secreted Extracellular Vesicles Inhibits Oxidative Stress in Parkinson’s Disease by Inhibiting EGR1 and NOX4

Researchers investigated the physiological mechanisms by which extracellular vesicle-encapsulated miR-181a–2–3p derived from mesenchymal stem cells might mediate oxidative stress in Parkinson’s disease.
[Cell Death Discovery]

Full Article

Identification and Functional Characterization of CD133⁺GFAP⁺CD117⁺Sca1⁺ Neural Stem Cells

C57BL/6 mice were used to isolate and identify CD133⁺GFAP⁺CD117⁺Sca1⁺ cells in the hippocampal dentate gyrus region of the mouse brain as a novel neural stem cell population, in terms of cell phenotype, self-renewal capacity, and differentiation capability.
[Molecular and Cellular Biochemistry]

Abstract

Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia.
[Current Stem Cell Research & Therapy]

Full Article

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REVIEWS

Pharmacological Brain Cytoprotection in Acute Ischaemic Stroke — Renewed Hope in the Reperfusion Era

Scientists review new types of clinical trials to evaluate whether cytoprotective drugs can slow infarct growth prior to reperfusion and/or ameliorate the consequences of reperfusion, such as hemorrhagic transformation.
[New England Journal of Medicine]

Full Article

Immunogenic Cell Death and Its Therapeutic or Prognostic Potential in High-Grade Glioma

Glioblastoma is the most lethal primary brain tumor with a dismal prognosis despite maximal therapy. The development of new therapies in this aggressive type of tumors remains highly challenging partially due to the cold tumor immune environment.
[Genes & Immunity]

Full Article

INDUSTRY AND POLICY NEWS

NTT Research to Collaborate with Researchers at Harvard University on Computational Neurobiology

NTT Research, Inc. announced that it has entered a joint research agreement with scientists at Harvard University to study animal neuro-responses with the hope of informing future artificial intelligence systems.
[NTT Research, Inc.]

Press Release

Athira Pharma Announces Initiation of Patient Dosing in SHAPE, a Phase II Clinical Trial of ATH-1017 for the Treatment of Parkinson’s Disease Dementia and Dementia with Lewy Bodies

Athira Pharma, Inc. announced that patient dosing has begun in SHAPE, a Phase II clinical trial of ATH-1017 for the treatment of Parkinson’s disease dementia and dementia with lewy bodies.
[Athira Pharma, Inc.]

Press Release

FEATURED EVENT

Tau Interactome Maps Synaptic and Mitochondrial Processes Associated with Neurodegeneration

Selective Translation of Epigenetic Modifiers Affects the Temporal Pattern and Differentiation of Neural Stem Cells

Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids

Midbrain Organoids Mimic Early Embryonic Neurodevelopment and Recapitulate LRRK2-p.Gly2019Ser-Associated Gene Expression

History-Dependent Dopamine Release Increases cAMP Levels in Most Basal Amygdala Glutamatergic Neurons to Control Learning

Irradiation Causes Senescence, ATP Release, and P2X7 Receptor Isoform Switch in Glioblastoma

Antisense Oligonucleotides as a Potential Treatment for Brain Deficits Observed in Myotonic Dystrophy Type 1

MicroRNA-181a–2–3p Shuttled by Mesenchymal Stem Cell-Secreted Extracellular Vesicles Inhibits Oxidative Stress in Parkinson’s Disease by Inhibiting EGR1 and NOX4

Identification and Functional Characterization of CD133⁺GFAP⁺CD117⁺Sca1⁺ Neural Stem Cells

Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

Pharmacological Brain Cytoprotection in Acute Ischaemic Stroke — Renewed Hope in the Reperfusion Era

Immunogenic Cell Death and Its Therapeutic or Prognostic Potential in High-Grade Glioma

NTT Research to Collaborate with Researchers at Harvard University on Computational Neurobiology

Athira Pharma Announces Initiation of Patient Dosing in SHAPE, a Phase II Clinical Trial of ATH-1017 for the Treatment of Parkinson’s Disease Dementia and Dementia with Lewy Bodies

The Australasian Society for Stem Cell Research (ASSCR) Annual Meeting

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PhD Position – Neurobiology

Senior Researcher – Neurobiology

PhD Position – Neurophysiology

Postdoctoral Research Associate – Drug Responses in Glioblastoma

Faculty Position – Neuroscience

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