| Vol. 7.03 – 31 January, 2022 |
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| Investigators profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity. [Science] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists constructed the single-cell transcriptomic landscape of vascular endothelial cells during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. [Cell Research] |
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| The authors showed that toll/interleukin-1 receptor domain containing adaptor protein (TIRAP) was overexpressed in various types of myelodysplastic syndromes and suppressed all three major hematopoietic lineages. [Journal of Experimental Medicine] |
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| Investigators described the identification of vimentin, an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers isolated endothelial progenitor cells derived from the human kidney and surveyed microRNA target transcripts. They used a genetic knockout model to evaluate the effect of deleting endogenous expression of miR-218 specifically in angioblasts. [Journal of the American Society of Nephrology] |
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| Scientists investigated the effect of reduced complement factor H (FH) levels in the choroid to determine whether increasing local FH could protect choroidal endothelial cells from membrane attack complex deposition. [Journal of Pathology] |
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| In this in vitro study scientists assessed the cytotoxic effects of nickel oxide nanoparticles (NiONPs) on human pulmonary artery endothelial cells. [Nanotoxicology] |
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| Oxidized low-density lipoprotein was used to treat HUVECs to construct a cell injury model. The expression level of circCHMP5, miR-532-5p, and Rho-associated protein kinase 2 was measured using quantitative real-time PCR. [Cardiovascular Drugs and Therapy] |
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| Researchers used global gene expression in human coronary artery endothelial cells to identify gene pathways and cellular processes in response to chemical hypoxia, oxidized lipids, IL-1β induced inflammation, oscillatory flow, and these combined stimuli. [Scientific Reports] |
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| The authors examine endothelial cell bone morphogenetic protein (BMP) signaling in vitro and in vivo and discuss the paradox of BMP signals that both destabilize and stabilize endothelial cell behaviors. [Cellular and Molecular Life Sciences] |
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| Idorsia Ltd and Idorsia Pharmaceuticals Japan announced that the Japanese Pharmaceuticals and Medical Devices Agency has approved PIVLAZâ„¢ 150mg, a selective endothelin A receptor antagonist, for the prevention of cerebral vasospasm, vasospasm-related cerebral infarction and cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. [Idorsia Ltd. (GlobeNewswire, Inc.)] |
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| ​The US FDA has approved the use of Genentech (Roche)’s Vabysmo for the treatment of wet age-related macular degeneration and diabetic macular edema. [BioSpace, Inc.] |
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| April 6 – 9, 2022 Heidelberg, Germany |
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| Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| University of Southern Denmark – Odense M, Denmark |
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| Columbia University – New York, New York, United States |
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| Ksilink – Strasbourg, France |
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| Howard Hughes Medical Institute – Dallas, Texas, United States |
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