| Vol. 14.07 – 25 February, 2022 |
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| Scientists demonstrated that a trispecific antibody to HER2, CD3 and CD28 stimulated regression of breast cancers in a humanized mouse model through a mechanism involving CD4-dependent inhibition of tumor cell cycle progression. [Nature] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated how changes to naive CD8+ T cell gene expression depended on the basic leucine zipper ATF-like transcription factor Batf, which was essential for the early phases of the process. [Science Immunology] |
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| The authors reported the identification of hepatitis C virus NS5A inhibitors Pibrentasvir and Ombitasvir as SARS-CoV-2 exonuclease inhibitors. [Communications Biology] |
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| Scientists tested whether perinatal intake of a multispecies probiotic could mitigate the abnormal emotional behavior in the juvenile and adult offspring of obese dams. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators used modeling to show that the unbinding rate of tandem, but not single, Src homology 2 domains could be accelerated by phosphatases. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that diminished expression of a model tissue-restricted antigen gene in aged thymic stromal cells correlated with impaired clonal deletion of cognate T cells recognizing an autoantigen involved in atherosclerosis. [Cell Reports] |
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| Scientists reported that mice with Treg cell–specific ablation of miR-142 developed a fatal systemic autoimmune disorder due to a breakdown in peripheral T cell tolerance. [PLoS Biology] |
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| Investigators evaluated the anti-inflammatory and antioxidant effects of 18β-GA in an ovalbumin-induced asthma mouse model, and examined the role of NF-κB and Nrf2/HO-1 signaling pathways. [Scientific Reports] |
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| Murine splenocytes were differentiated into T helper 17 cells, and the effect of the TGF-βRI inhibitor SB-505124 was studied. [Scientific Reports] |
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| IL-2 biologics have proven to be effective in preclinical studies and clinical assessment of some is now underway. [Nature Reviews Immunology] |
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| Investigators hypothesize that memory responses to antigens from the microbiota must be ‘licensed’ by inflammatory signals activated by invasion of the host by microorganisms. [Mucosal Immunology] |
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| MyMD Pharmaceuticals, Inc. announced that the first patient has been enrolled in the company’s Phase II clinical trial of lead candidate MYMD-1, an oral immune regulator drug, as a therapy for delaying aging and expanding healthy lifespan. [MyMD Pharmaceuticals, Inc. (BusinessWire, Inc.)] |
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| Dr. Vishva Dixit has received the Vilcek Prize in Biomedical Science for his groundbreaking discoveries on the mechanism of apoptosis. [The Vilceck Foundation] |
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| March 19 – 22, 2022 Sitges, Spain |
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| Genetech – South San Francisco, California, United States of America |
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| University of Lausanne – Lausanne, Switzerland |
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| Columbia University – New York, New York, United States |
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| TU Dresden – Dresden, Germany |
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| Babraham Institute – Babraham, England, United Kingdom |
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