| Vol. 6.13 – 8 April, 2022 |
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| Scientists studied heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that ketohexokinase expression was tightly controlled and limited to a small number of organs and was down-regulated in liver and intestinal cancer cells. [Science Advances] |
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| The authors identified reverse signaling between glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) as a cross-interaction pathway between immune cells and hepatic stem/progenitor cells that restricted the expansion of hepatic stem/progenitor cells and reduced the possibility of carcinogenesis. [Cell Death & Disease] |
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| Researchers studied the proferroptosis effect and mechanism of mesenchymal stem cell-ex in hepatic stellate cells. [Cell Death & Disease] |
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| The authors investigated the differential regulatory effect of metabotropic glutamate receptor 5 on chemosensitivity in HCC and chemotoxicity to the normal liver. [Cancer Gene Therapy] |
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| Scientists found that specific deletion of Cbl-b and c-Cbl in CD11c+ cells, predominantly in dendritic cells (DCs), led to liver fibrosis, cirrhosis, and accumulation of systemic conventional Type I DCs due to enhanced cell proliferation and decreased cell apoptosis. [Cell Death Discovery] |
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| The biological role and mechanism of nociceptin receptor in HCC tumor growth was determined in vitro and in vivo. [Cell Death Discovery] |
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| Researchers investigated the role of proprotein convertase subtilisin kexin type 9 (PCSK9) and explored the therapeutic effect of metformin for olanzapine-associated non-alcoholic fatty liver disease. [Scientific Reports] |
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| Investigators suggested that LRP1B played an essential role in the promotion of HCC progression by regulating the PERK-ATF4-CHOP signaling pathway, which is a potential prognostic biomarker and a promising therapeutic target of HCC. [Bioengineered] |
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| After co-culture systems of M2 macrophages and HCC cells were established, it was shown that co-culture with M2 macrophages could promote both the proliferation and invasion of HepG2 and Huh7 cells. [Bioengineered] |
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| The authors summarize the biogenesis, characterization and biological functions, recent detection and identification technologies of circRNA, and regulation network mechanism of circRNA in liver diseases [Cancer Cell International] |
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| Mursla announced that it has secured mentorship support from Roche Diagnostics, Ltd. for a new liquid biopsy prospective pilot study for liver cancer surveillance through MedCity’s Collaborate to Innovate: London Diagnostics program. [Mursla] |
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| June 9 – 13, 2022 Washington, DC, United States |
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| Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| NIH National Institute on Alcohol Abuse and Alcoholism – Bethesda, Maryland, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Genentech, Inc. – South San Francisco, California, United States |
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| Gilead Sciences – Foster City, California, United States |
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