| Vol. 7.12 – 11 April, 2022 |
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| Scientists studied the heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Electrophysiological analyses confirmed expression and function of Piezo1 channels in brain cortical and retinal capillaries. Activation of Piezo1 channels evoked currents that were sensitive to endothelial cell–specific Piezo1 deletion. [Circulation Research] |
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| The authors investigated if focal ablation of astrocytes was sufficient to disrupt the blood-brain barrier in mice. Targeted two-photon chemical apoptotic ablation of astrocytes induced a plasticity response whereby surrounding astrocytes extended processes to cover vascular vacancies. [Nature Communications] |
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| Researchers developed an efficient and scalable protocol to produce human pluripotent stem cell (hPSC)-derived liver sinusoidal endothelial cells progenitors characterized as venous endothelial cells from different mesoderm subpopulations. [Cell Reports] |
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| Endothelial epithelial Na+ channel (ENaC), together with the glycocalyx, was identified as an important shear stress sensor and mediator of endothelium-dependent vasodilation. [Cellular and Molecular Life Sciences] |
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| Scientists showed that the deficiency of miRNA-22a, an endothelial-enriched miRNA, caused dramatic pathfinding defects both in intersegmental vessels and primary motor neurons in zebrafish embryos. [Open Biology] |
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| Investigators showed that exosomes from Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) cells, but not exosomes from EBV-negative NPC cells, destroyed endothelial cell tight junction proteins and promoted endothelial-to-mesenchymal transition in endothelial cells. [Cancer Gene Therapy] |
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| The authors used single-cell RNA sequencing to explore the transcriptomic landscape of mid- and advanced-stage alcohol-induced osteonecrosis of the femoral head. [Communications Biology] |
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| Researchers elucidated the overall smoking-induced miRNA changes and those specific to chronic obstructive pulmonary disease (COPD).They investigated the downstream effects on regulatory gene expression and the correlation to cellular composition. [Scientific Reports] |
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| Investigators describe an innovative screening platform for the identification of new blood-brain barrier targeting molecules from a class of lamprey antigen-recognition proteins known as variable lymphocyte receptors. [Scientific Reports] |
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| Researchers investigated the cardiovascular effects of the Croton urucurana extract in spontaneously hypertensive rats. [Journal of Ethnopharmacology] |
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| Scientists discuss factors that contribute to cardiovascular disease in systemic lupus erythematosus (SLE), with particular focus on how endothelial function and endothelial progenitor cells (EPCs) are evaluated currently, and how EPCs are quantitatively and functionally altered in patients with SLE. [Nature Reviews Rheumatology] |
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| Adrenomed AG announced that its proprietary sepsis drug candidate Adrecizumab received a funding commitment of €7.4 million from the German Federal Ministry of Education and Research as part of the German funding initiatives for the clinical development of COVID-19 drugs. [Adrenomed AG] |
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| Acer Therapeutics, Inc. announced the FDA has granted celiprolol breakthrough therapy designation in the US for the treatment of patients with COL3A1-positive vascular Ehlers-Danlos syndrome. [Acer Therapeutics, Inc.] |
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| May 25 – 27, 2022 Hinxton, England, United Kingdom |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| University of Copenhagen – Copenhagen, Denmark |
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| The Wellcome Trust – London, England, United Kingdom |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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