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A Diabetic Milieu Increases ACE2 Expression and Cellular Susceptibility to SARS-CoV-2 Infections in Human Kidney Organoids and Patient Cells | Isolated from kidney biopsies from diabetic patients exhibited altered mitochondrial respiration and enhanced glycolysis, resulting in higher SARS-CoV-2 infections compared with non-diabetic cells. [Cell Metabolism] |
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PUBLICATIONSRanked by the impact factor of the journal |
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Soft, Dynamic Hydrogel Confinement Improves Kidney Organoid Lumen Morphology and Reduces Epithelial–Mesenchymal Transition in Culture | Various dynamic hydrogel architectures were created, conferring a controlled and biomimetic environment for organoid encapsulation. [Advanced Science] |
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UNC45A Deficiency Causes Microvillus Inclusion Disease–Like Phenotype by Impairing Myosin VB–Dependent Apical Trafficking | Patients and UNC45AKO 3D organoids displayed altered luminal development and microvillus inclusions, while 2D cultures revealed Rab11 and apical transporter mislocalization as well as sparse and disorganized microvilli. [Journal of Clinical Investigation] |
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Hesperadin Suppresses Pancreatic Cancer through ATF4/GADD45A Axis at Nanomolar Concentrations | Hesperadin induced potent growth inhibition in pancreatic cancer cell lines and patient-derived tumor organoids in a dose- and time-dependent manner, with IC50 values in the nanomolar range. [Oncogene] |
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Large-Scale Engineering of hiPSC-Derived Nephron Sheets and Cryopreservation of Their Progenitors | Investigators developed a scalable, easily accessible, and reproducible protocol to increase the size of the organoid up to a nephron sheet of 2.5 cm2 up to a maximum of 12.6 cm2 containing a magnitude of nephrons. [Stem Cell Research & Therapy] |
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Apical-Out Airway Organoids as a Platform for Studying Viral Infections and Screening for Antiviral Drugs | The authors described a scalable, fast and efficient way to generate airway organoids with the apical side externally exposed. [Scientific Reports] |
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Derivation of Hormone-Responsive Human Endometrial Organoids and Stromal Cells from Cryopreserved Biopsies | Scientists sought to develop an efficient, simple, robust and reproducible method to cryopreserve human endometrial biopsies that could be stored and/or shipped frozen and later thawed to generate endometrial organoids and endometrial stromal cells. [Experimental Cell Research] |
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Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids | Investigators sought to recapitulate Sal4-mediated protection against serovar Typhimurium in human enteroids and human intestinal organoids as models to decipher the molecular mechanisms by which antibodies function in mucosal immunity in the human gastrointestinal tract. [Infection and Immunity] |
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Generation of Functional Fat Organoid from Rat Superficial Fascia | Researchers investigated superficial fascia fragments in 3D hydrogel and found they were able to transform into relatively large adipocyte aggregates containing mature unilocular adipocytes, which were virtually “fat organoids”. [Adipocyte] |
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Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System | The authors discuss recent findings in the field of bioelectricity relating to the central nervous system, possible mechanisms, and how electrical stimulation may be utilized as a novel technique to engineer “next-generation” organoids. [Frontiers in Cell and Developmental Biology] |
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Physiology Assays in Human Kidney Organoids | Scientists review assays of physiological function in human kidney organoids, including best practices for quality control, and future applications. [American Journal of Physiology-Renal Physiology] |
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Thirteen from MIT awarded 2022 Fulbright Fellowships | Thirteen MIT undergraduates, graduate students, and alumni have been awarded Fulbright fellowships to pursue projects overseas in the 2022-23 grant year. [Massachusetts Institute of Technology] |
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| September 19 – September 20 2022 Vejle, Denmark |
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| STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| Jülich Research Centre – Jülich, Germany |
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| IGBMC – Illkirch-Graffenstaden, France |
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| Hubrecht Organoid Technology – Utrecht, Netherlands |
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