Organoid News Volume 3.19 | May 19 2022

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    2022-05-19 | ON 3.19


    Organoid News by STEMCELL Technologies
    Vol. 3.19 – 19 May, 2022
    TOP STORY

    A Diabetic Milieu Increases ACE2 Expression and Cellular Susceptibility to SARS-CoV-2 Infections in Human Kidney Organoids and Patient Cells

    Isolated from kidney biopsies from diabetic patients exhibited altered mitochondrial respiration and enhanced glycolysis, resulting in higher SARS-CoV-2 infections compared with non-diabetic cells.
    [Cell Metabolism]

    Full ArticleGraphical Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Soft, Dynamic Hydrogel Confinement Improves Kidney Organoid Lumen Morphology and Reduces Epithelial–Mesenchymal Transition in Culture

    Various dynamic hydrogel architectures were created, conferring a controlled and biomimetic environment for organoid encapsulation.
    [Advanced Science]

    Full Article

    UNC45A Deficiency Causes Microvillus Inclusion Disease–Like Phenotype by Impairing Myosin VB–Dependent Apical Trafficking

    Patients and UNC45AKO 3D organoids displayed altered luminal development and microvillus inclusions, while 2D cultures revealed Rab11 and apical transporter mislocalization as well as sparse and disorganized microvilli.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Hesperadin Suppresses Pancreatic Cancer through ATF4/GADD45A Axis at Nanomolar Concentrations

    Hesperadin induced potent growth inhibition in pancreatic cancer cell lines and patient-derived tumor organoids in a dose- and time-dependent manner, with IC50 values in the nanomolar range.
    [Oncogene]

    Abstract

    Large-Scale Engineering of hiPSC-Derived Nephron Sheets and Cryopreservation of Their Progenitors

    Investigators developed a scalable, easily accessible, and reproducible protocol to increase the size of the organoid up to a nephron sheet of 2.5 cm2 up to a maximum of 12.6 cm2 containing a magnitude of nephrons.
    [Stem Cell Research & Therapy]

    Full Article

    Apical-Out Airway Organoids as a Platform for Studying Viral Infections and Screening for Antiviral Drugs

    The authors described a scalable, fast and efficient way to generate airway organoids with the apical side externally exposed.
    [Scientific Reports]

    Full Article

    Derivation of Hormone-Responsive Human Endometrial Organoids and Stromal Cells from Cryopreserved Biopsies

    Scientists sought to develop an efficient, simple, robust and reproducible method to cryopreserve human endometrial biopsies that could be stored and/or shipped frozen and later thawed to generate endometrial organoids and endometrial stromal cells.
    [Experimental Cell Research]

    Abstract

    Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids

    Investigators sought to recapitulate Sal4-mediated protection against serovar Typhimurium in human enteroids and human intestinal organoids as models to decipher the molecular mechanisms by which antibodies function in mucosal immunity in the human gastrointestinal tract.
    [Infection and Immunity]

    Abstract

    Generation of Functional Fat Organoid from Rat Superficial Fascia

    Researchers investigated superficial fascia fragments in 3D hydrogel and found they were able to transform into relatively large adipocyte aggregates containing mature unilocular adipocytes, which were virtually “fat organoids”.
    [Adipocyte]

    Abstract
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

    The authors discuss recent findings in the field of bioelectricity relating to the central nervous system, possible mechanisms, and how electrical stimulation may be utilized as a novel technique to engineer “next-generation” organoids.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Physiology Assays in Human Kidney Organoids

    Scientists review assays of physiological function in human kidney organoids, including best practices for quality control, and future applications.
    [American Journal of Physiology-Renal Physiology]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Thirteen from MIT awarded 2022 Fulbright Fellowships

    Thirteen MIT undergraduates, graduate students, and alumni have been awarded Fulbright fellowships to pursue projects overseas in the 2022-23 grant year.
    [Massachusetts Institute of Technology]

    Press Release
    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – September 20 2022
    Vejle, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Principal Investigator – Interdisciplinary Research in Biology

    CNRS – Paris, France

    Research Technologist – Bioengineering

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    PhD Position – Mechanobiology

    Jülich Research Centre – Jülich, Germany

    Engineer – Organoid Growth

    IGBMC – Illkirch-Graffenstaden, France

    Research Associate – Culturing 3D Organoids

    Hubrecht Organoid Technology – Utrecht, Netherlands

    > See All Jobs

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