| Vol. 14.18 – 20 May, 2022 |
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Activation of the Transcription Factor NRF2 Mediates the Anti-Inflammatory Properties of a Subset of Over-the-Counter and Prescription NSAIDs | Using genetic and pharmacologic approaches, the authors found that nonsteroidal anti-inflammatory drug (NSAID)-mediated GDF15 induction was dependent on the activation of nuclear factor erythroid 2-related factor 2 (NRF2) in myeloid cells. [Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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Zbtb20 Identifies and Controls a Thymus-Derived Population of Regulatory T Cells That Play a Role in Intestinal Homeostasis | Zbtb20 expression identified and controlled the function of a distinct subset of Tregs that were involved in intestinal homeostasis. [Science Immunology] |
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The Phosphatase PTEN Links Platelets with Immune Regulatory Functions of Mouse T Follicular Helper Cells | Investigators showed that mice with platelet-specific deletion of phosphatase and tensin homolog (Pten) developed age-related lymphoproliferative diseases and humoral autoimmunity not seen in wildtype animals. [Nature Communications] |
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The Ubiquitin Ligase Cul5 Regulates CD4+ T Cell Fate Choice and Allergic Inflammation | Researchers showed that the E3 ubiquitin ligase Cul5 determined fate selection in CD4+ T cells by regulating IL-4 receptor signaling. [Nature Communications] |
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ATP Spreads Inflammation to Other Limbs through Crosstalk between Sensory Neurons and Interneurons | The authors showed that ATP served as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induced inflammation on the other side. [Journal of Experimental Medicine] |
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Claudin-12 Deficiency Inhibits Tumor Growth by Impairing Transendothelial Migration of Myeloid-Derived Suppressor Cells | Scientists used mice deficient in tight-junction protein Claudin-12 (Cldn12) compared to wild-type mice and found that loss of host Cldn12 inhibited the growth of transplanted tumors, reduced intratumoral accumulation of myeloid-derived suppressor cells, increased anti-tumor immune responses, and decreased tumor vescular density. [Cancer Research] |
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Insights into Immune Escape during Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer | Investigators showed that Nitroso-N-methylurea–induced mammary tumors in outbred Sprague-Dawley rats recapitulated the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer. [Cancer Immunology Research] |
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Retinoic Acid Signaling Acts as a Rheostat to Balance Treg Function | Researchers employed mouse models in which retinoic acid (RA) signaling was silenced by the expression of the dominant negative receptor RARα in all T cells. [Cellular & Molecular Immunology] |
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WEE1 Inhibition Enhances the Antitumor Immune Response to PD-L1 Blockade by the Concomitant Activation of STING and STAT1 Pathways in SCLC | The authors demonstrated cell-autonomous and immune-stimulating activity of WEE1 inhibition in small cell lung cancer (SCLC) models. [Cell Reports] |
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Myeloid Cell-Specific Topoisomerase 1 Inhibition Using DNA Origami Mitigates Neuroinflammation | Investigators showed that topoisomerase 1 (TOP1) was highly expressed in neuroinflammatory conditions, and TOP1 inhibition using camptothecin and its FDA-approved analog topotecan reduced inflammatory responses in microglia/macrophages and ameliorated neuroinflammation in vivo. [EMBO Reports] |
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Recruitment of Monocytes Primed to Express Heme Oxygenase-1 Ameliorates Pathological Lung Inflammation in Cystic Fibrosis | Scientists revealed the mechanism of action of PP-007 responsible for the immunomodulatory function observed in clinical trials for a wide range of diseases and demonstrated the potential use of PP-007 in controlling neutrophilic pulmonary inflammation by promoting the expression of HO-1 in monocytes/macrophages. [Experimental & Molecular Medicine] |
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Variants of Beta-Glucan Polysaccharides Downregulate Autoimmune Inflammation | Researchers investigated the effects of β-glucan polysaccharides in the effector phase of arthritis and as regulators of psoriasis and psoriatic arthritis-like symptoms in mice. [Communications Biology] |
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Peripheral NOD-Like Receptor Deficient Inflammatory Macrophages Trigger Neutrophil Infiltration into the Brain Disrupting Daytime Locomotion | Scientists investigated whether inappropriate macrophage-evoked inflammation altered central nervous system control of daily-life animal locomotion using a set of zebrafish mutants selected for specific macrophage dysfunction and microglia deficiency. [Communications Biology] |
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Immunosuppressive Cells in Cancer: Mechanisms and Potential Therapeutic Targets | The authors summarize the phenotype, function, and potential therapeutic targets of immunosuppressive cells in the tumor microenvironment. [Journal of Hematology & Oncology] |
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Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease | Scientists review the latest progress on type 2 innate lymphoid cells (ILC2s) and CD4+T cells in the lung, the close relationship between the two, and their relevance in the lung disease and immunity. [Journal of Immunology Research] |
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Surrozen Initiates Dosing in Phase I Clinical Trial of SZN-1326 for Moderate to Severe Ulcerative Colitis | Surrozen, Inc. announced that the first subject has been dosed in its three-part Phase I clinical trial to evaluate SZN-1326 for the potential treatment of moderate to severe ulcerative colitis. [Surrozen, Inc.] |
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Research Animals Mistreated by Leading Supplier, Animal Welfare Group Alleges | The contract research organization Inotiv is neglecting animals at a research facility in Indiana that conducts toxicity testing of experimental drugs, the Humane Society of the United States alleged. [ScienceInsider] |
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| June 16 – 17, 2022 Leuven, Belgium |
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| Karolinska Institute – Stockholm, Sweden |
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| University of Oxford – Oxford, England, United Kingdom |
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| STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| Cancer Research Center of Lyon – Lyon, France |
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| New York University College of Dentistry – New York, New York, United States |
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