| Vol. 3.38 – 29 September, 2022 |
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| Researchers performed transcriptome profiling of 350 libraries from six tissues in mouse models harboring copy-number variants (CNVs) of the syntenic 7qF3 region. [American Journal of Human Genetics] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified that ARRB1 played essential roles in mediating gastric cancer cell metabolism and proliferation, by combining cohort analysis and functional investigation using patient-derived preclinical models. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators generated a series of human iPSC lines bearing pathogenic missense variants of NPHS2, encoding the protein changes p.G92C, p.P118L, p.R138Q, p.R168H and p.R291W, as well as control lines. [Journal of the American Society of Nephrology] |
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| Researchers presented a new strategy to establish placenta-like organoids with vascular-like structures from human-induced pluripotent stem cells in a defined three-dimensional culture system. [Bioengineering & Translational Medicine] |
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| Scientists demonstrated that a major contributor to cortical organoid quality is the way hPSCs are maintained prior to differentiation. [Stem Cell Reports] |
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| A 2D-3D differentiation method was used to generate retinal organoids, which were cultured with or without the most commonly used media supplements, notably retinoic acid. [Stem Cell Research & Therapy] |
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| The effects of type I IFN, IFN-γ, and TNF-α on gene expression, cytokine production and cell death were investigated in human colonic organoids. [American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| The effects of CKD-506 on gut barrier function in a cell line and colon organoids, based on examinations of mRNA production, goblet cell differentiation, and E-cadherin recovery, were investigated using quantitative rtPCR, immunofluorescence, and a fluorescein isothiocyanate-dextran permeability assay. [Gut and Liver] |
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Investigators presented a method that overcame the reproducibility and scalability limitations of organoids by using deep-learning-driven analysis for phenotypic drug screens based on highly standardized micropattern-based neural organoids. [Cell Reports Methods] |
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| The authors provide an overview of the current state of functional precision medicine, highlight advances for drug-sensitivity screening enabled by cell culture models, and discuss how artificial intelligence can be coupled to functional precision medicine to guide patient stratification. [Trends in Pharmacological Sciences] |
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| Over the past few decades, the use of organoids has led to an advanced understanding of the composition of each digestive organ and has facilitated disease modeling, chemotherapy dose prediction, CRISPR-Cas9 genetic intervention, high-throughput drug screening, and identification of SARS-CoV-2 targets. [Signal Transduction and Targeted Therapy] |
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| Crown Bioscience & MBL, a joint venture between two JSR Life Sciences companies formed earlier this year, announced the launch of their full-service drug discovery and development capabilities in Japan. [Crown Bioscience] |
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| November 6 – 8, 2022 Seville, Spain |
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| University of Miami – Miami, Florida, United States |
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| Syracuse University – Syracuse, New York, United States |
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| NIH – Research Triangle Park, North Carolina, United States |
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| European Molecular Biology Laboratory – Barcelona, Spain |
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| Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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