Organoid News Volume 3.38 | Sep 29 2022

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    2022-09-29 | ON 3.38


    Organoid News by STEMCELL Technologies
    Vol. 3.38 – 29 September, 2022
    TOP STORY

    Tissue- and Cell-Type-Specific Molecular and Functional Signatures of 16p11.2 Reciprocal Genomic Disorder Across Mouse Brain and Human Neuronal Models

    Researchers performed transcriptome profiling of 350 libraries from six tissues in mouse models harboring copy-number variants (CNVs) of the syntenic 7qF3 region.
    [American Journal of Human Genetics]

    AbstractGraphical Abstract
    Webinar: Organoids as Models for Human Disease
    PUBLICATIONSRanked by the impact factor of the journal

    Dual Roles of β-Arrestin 1 in Mediating Cell Metabolism and Proliferation in Gastric Cancer

    The authors identified that ARRB1 played essential roles in mediating gastric cancer cell metabolism and proliferation, by combining cohort analysis and functional investigation using patient-derived preclinical models.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking

    Investigators generated a series of human iPSC lines bearing pathogenic missense variants of NPHS2, encoding the protein changes p.G92C, p.P118L, p.R138Q, p.R168H and p.R291W, as well as control lines.
    [Journal of the American Society of Nephrology]

    Abstract

    Engineering Placenta-Like Organoids Containing Endogenous Vascular Cells from Human-Induced Pluripotent Stem Cells

    Researchers presented a new strategy to establish placenta-like organoids with vascular-like structures from human-induced pluripotent stem cells in a defined three-dimensional culture system.
    [Bioengineering & Translational Medicine]

    Full Article

    TGFβ Superfamily Signaling Regulates the State of Human Stem Cell Pluripotency and Capacity To Create Well-Structured Telencephalic Organoids

    Scientists demonstrated that a major contributor to cortical organoid quality is the way hPSCs are maintained prior to differentiation.
    [Stem Cell Reports]

    Full Article

    Retinoic Acid Delays Initial Photoreceptor Differentiation and Results in a Highly Structured Mature Retinal Organoid

    A 2D-3D differentiation method was used to generate retinal organoids, which were cultured with or without the most commonly used media supplements, notably retinoic acid.
    [Stem Cell Research & Therapy]

    Full Article

    DNA Sensor Associated Type I Interferon Signaling Is Increased in Ulcerative Colitis and Induces JAK-Dependent Inflammatory Cell Death in Colonic Organoids

    The effects of type I IFN, IFN-γ, and TNF-α on gene expression, cytokine production and cell death were investigated in human colonic organoids.
    [American Journal of Physiology-Gastrointestinal and Liver Physiology]

    Abstract

    Novel Histone Deacetylase 6 Inhibitor Confers Anti-Inflammatory Effects and Enhances Gut Barrier Function

    The effects of CKD-506 on gut barrier function in a cell line and colon organoids, based on examinations of mRNA production, goblet cell differentiation, and E-cadherin recovery, were investigated using quantitative rtPCR, immunofluorescence, and a fluorescein isothiocyanate-dextran permeability assay.
    [Gut and Liver]

    Full Article

    Deep-Learning Analysis of Micropattern-Based Organoids Enables High-Throughput Drug Screening of Huntington’s Disease Models

    Investigators presented a method that overcame the reproducibility and scalability limitations of organoids by using deep-learning-driven analysis for phenotypic drug screens based on highly standardized micropattern-based neural organoids.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract
    In this webinar on hepatic organoids review the biological characteristics and practical considerations of adding organoids to your research.
    REVIEWS

    Functional Precision Cancer Medicine: Drug Sensitivity Screening Enabled by Cell Culture Models

    The authors provide an overview of the current state of functional precision medicine, highlight advances for drug-sensitivity screening enabled by cell culture models, and discuss how artificial intelligence can be coupled to functional precision medicine to guide patient stratification.
    [Trends in Pharmacological Sciences]

    Full Article

    Applications of Human Organoids in the Personalized Treatment for Digestive Diseases

    Over the past few decades, the use of organoids has led to an advanced understanding of the composition of each digestive organ and has facilitated disease modeling, chemotherapy dose prediction, CRISPR-Cas9 genetic intervention, high-throughput drug screening, and identification of SARS-CoV-2 targets.
    [Signal Transduction and Targeted Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Crown Bioscience & MBL Launch Joint Venture To Serve Japanese Biopharmaceutical Community

    Crown Bioscience & MBL, a joint venture between two JSR Life Sciences companies formed earlier this year, announced the launch of their full-service drug discovery and development capabilities in Japan.
    [Crown Bioscience]

    Press Release

    FEATURED EVENT

    Cell Symposia: Multifaceted Mitochondria

    November 6 – 8, 2022
    Seville, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Chromosomal Architecture

    University of Miami – Miami, Florida, United States

    Postdoctoral Position – Stem Cell Organoids

    Syracuse University – Syracuse, New York, United States

    Senior Investigator – Stem Cell Biology

    NIH – Research Triangle Park, North Carolina, United States

    Research Technician – 3DVasCMD

    European Molecular Biology Laboratory – Barcelona, Spain

    PhD Fellowship – Gene Therapy

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    > See All Jobs

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