| Vol. 14.37 – 21 October, 2022 |
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| Susd2−/− effector CD8+ T cells showed enhanced production of antitumor molecules, which consequently blunted tumor growth in multiple syngeneic mouse tumor models. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers conducted a comprehensive phenotypic and functional investigation of immune cell responses from nonallergic and peanut allergic participants cultured with media alone or with peanut protein. [Journal of Clinical Investigation] |
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| Lung-restricted autoantibodies-mediated injury was localized to the transplanted lung and dependent on interleukin (IL)-1β–mediated permeabilization of pulmonary vascular endothelium, which allowed extravasation of antibodies [Journal of Clinical Investigation] |
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| The authors conditionally inactivated Tcf7 in CD4 expressing T cells in a mouse model of pancreatic cancer and observed changes in the tumor immune microenvironment. [Journal of Experimental Medicine] |
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| Scientists identified tumor microenvironment-specific SPP1-expressing macrophages with altered metabolism features, foam cell characteristics and increased activity in extracellular matrix organization. [Clinical Cancer Research] |
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| Investigators found that the inner mitochondrial membrane protein prohibitin played a critical role in mtDNA release by regulating permeability across the mitochondrial inner membrane. [EMBO Journal] |
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| Researchers leveraged structural insights to engineer a single-chain human interleukin-2/F5111 antibody fusion protein, termed F5111 immunocytokine, which potently and selectively activated and expanded Tregs. [Cell Reports] |
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| The authors discovered that plasma High Mobility Group Box 1 Protein correlated negatively with platelet counts in immune thrombocytopenia (ITP) patients, and found that 18β-GA alleviated thrombocytopenia in ITP mice. [Haematologica] |
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| Using a lymphocytic choriomeningitis virus Armstrong infection mouse model, researchers found that Treg cell-derived interleukin (IL)-15 was required for long-term maintenance of the KLRG1+IL-7Rα−CD62L− terminal effector memory CD8+ T cell subset. [European Journal of Immunology] |
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| Scientists tested the potential of teriflunomide, an immunomodulatory drug currently used in rheumatoid arthritis and multiple sclerosis treatment, in a murine experimental autoimmune myasthenia gravis model. [Cellular and Molecular Neurobiology] |
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| Invesitgators and clinical trials over the past few decades have elucidated the mechanisms underlying immunotherapy-induced tolerance, involving a reduction of allergen-specific T helper 2 cells, an induction of regulatory T and B cells, and the production of IgG and IgA ‘blocking’ antibodies. [Nature Reviews Immunology] |
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| Quoin Pharmaceuticals Ltd. announced that it has begun initiating a second clinical trial in Netherton Syndrome patients. This multicenter, open-label study will be being conducted under Quoin’s currently open US Investigational New Drug Application. [Quoin Pharmaceuticals Ltd.] |
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| December 10 – 14, 2022 Maui, Hawaii, United States |
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| King’s College London – London, England, United Kingdom |
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| Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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| AstraZeneca – Gaithersburg, Maryland, United States |
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| University of Florida – Gainesville, Florida, United States |
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| Luxembourg Institute of Health – Luxembourg, Luxembourg |
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