Immune Regulation News Volume 14.37 | Oct 21 2022

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    2022-10-21 | IRN 14.37


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.37 – 21 October, 2022
    TOP STORY

    SUSD2 Suppresses CD8+ T Cell Antitumor Immunity by Targeting IL-2 Receptor Signaling

    Susd2−/− effector CD8+ T cells showed enhanced production of antitumor molecules, which consequently blunted tumor growth in multiple syngeneic mouse tumor models.
    [Nature Immunology]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Cytometric Analysis Reveals an Association between Allergen-Responsive Natural Killer Cells and Human Peanut Allergy

    Researchers conducted a comprehensive phenotypic and functional investigation of immune cell responses from nonallergic and peanut allergic participants cultured with media alone or with peanut protein.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    IL-1β–Dependent Extravasation of Preexisting Lung-Restricted Autoantibodies during Lung Transplantation Activates Complement and Mediates Primary Graft Dysfunction

    Lung-restricted autoantibodies-mediated injury was localized to the transplanted lung and dependent on interleukin (IL)-1β–mediated permeabilization of pulmonary vascular endothelium, which allowed extravasation of antibodies
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    WNT Signaling in the Tumor Microenvironment Promotes Immunosuppression in Murine Pancreatic Cancer

    The authors conditionally inactivated Tcf7 in CD4 expressing T cells in a mouse model of pancreatic cancer and observed changes in the tumor immune microenvironment.
    [Journal of Experimental Medicine]

    Full Article

    Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor Associated SPP1+ Macrophages and Fibroblasts

    Scientists identified tumor microenvironment-specific SPP1-expressing macrophages with altered metabolism features, foam cell characteristics and increased activity in extracellular matrix organization.
    [Clinical Cancer Research]

    Abstract

    Prohibitin 1 Regulates mtDNA Release and Downstream Inflammatory Responses

    Investigators found that the inner mitochondrial membrane protein prohibitin played a critical role in mtDNA release by regulating permeability across the mitochondrial inner membrane.
    [EMBO Journal]

    AbstractGraphical Abstract

    Engineered Human Cytokine/Antibody Fusion Proteins Expand Regulatory T Cells and Confer Autoimmune Disease Protection

    Researchers leveraged structural insights to engineer a single-chain human interleukin-2/F5111 antibody fusion protein, termed F5111 immunocytokine, which potently and selectively activated and expanded Tregs.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Enhancing Regulatory T Cell Function via Inhibition of High Mobility Group Box 1 Protein Signaling in Immune Thrombocytopenia

    The authors discovered that plasma High Mobility Group Box 1 Protein correlated negatively with platelet counts in immune thrombocytopenia (ITP) patients, and found that 18β-GA alleviated thrombocytopenia in ITP mice.
    [Haematologica]

    Abstract

    Regulatory T Cell-Derived Interleukin-15 Promotes the Diversity of Immunological Memory

    Using a lymphocytic choriomeningitis virus Armstrong infection mouse model, researchers found that Treg cell-derived interleukin (IL)-15 was required for long-term maintenance of the KLRG1+IL-7Rα−CD62L− terminal effector memory CD8+ T cell subset.
    [European Journal of Immunology]

    Abstract

    The Beneficial Clinical Effects of Teriflunomide in Experimental Autoimmune Myasthenia Gravis and the Investigation of the Possible Immunological Mechanisms

    Scientists tested the potential of teriflunomide, an immunomodulatory drug currently used in rheumatoid arthritis and multiple sclerosis treatment, in a murine experimental autoimmune myasthenia gravis model.
    [Cellular and Molecular Neurobiology]

    AbstractGraphical Abstract
    Which Immune cell Are You?
    REVIEWS

    Allergen Immunotherapy: Past, Present and Future

    Invesitgators and clinical trials over the past few decades have elucidated the mechanisms underlying immunotherapy-induced tolerance, involving a reduction of allergen-specific T helper 2 cells, an induction of regulatory T and B cells, and the production of IgG and IgA ‘blocking’ antibodies.
    [Nature Reviews Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Quoin Pharmaceuticals Announces Plans to Initiate a Second Clinical Trial in Netherton Syndrome Patients

    Quoin Pharmaceuticals Ltd. announced that it has begun initiating a second clinical trial in Netherton Syndrome patients. This multicenter, open-label study will be being conducted under Quoin’s currently open US Investigational New Drug Application.
    [Quoin Pharmaceuticals Ltd.]

    Press Release
    FEATURED EVENT

    12th AACR-JCA Conference: Breakthroughs in Cancer Research

    December 10 – 14, 2022
    Maui, Hawaii, United States

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    JOB OPPORTUNITIES

    Research Associate – Aplastic Anaemia Pathophysiology

    King’s College London – London, England, United Kingdom

    Postdoctoral Position – Computational Biology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Associate Scientist – Bioscience Immunology

    AstraZeneca – Gaithersburg, Maryland, United States

    Postdoctoral Associate – Respiratory Infections

    University of Florida – Gainesville, Florida, United States

    PhD Student Positions – Tumor Ecosystem

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    > See All Jobs

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