| Vol. 13.29 – 2 December, 2022 |
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| Scientists observed an enrichment of transcription factor genes including HNF1B within prostate cancer (PCa) risk-associated regions. They found a strong expression quantitative trait locus for HNF1B and multiple potential causal variants involved in the regulation of HNF1B expression in PCa. [Nature Communications] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that AT-rich interactive domain-containing proteins 1 A (ARID1A), a subunit of the SWI/SNF chromatin remodeling complex, functioned downstream of inflammation-induced IKKβ activation to shape the immunosuppressive tumor microenvironment. [Nature Communications] |
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| Saikosaponin A (SSA) was posed as a novel quiescent cancer cell (QCC)-eradicating agent by aggravating autophagy in QCCs. In combination with the current therapy, SSA had potential to improve treatment effectiveness and to prevent cancer recurrence. [Cancer Letters] |
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| The authors reported an approach for suppressing reactivated androgen receptor (AR) signaling in the castration-resistant prostate cancer stage. A combination of tautomycin and enzalutamide synergistically inhibited cell proliferation and AR signaling in LNCaP, C4-2, and 22RV1 cells. [Cell Death Discovery] |
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| The LNCaP-androgen dependent cell line was cultured and passaged 60 times over 16 months. The morphology of the LNCaP-androgen independent (AI) cell line was observed. Androgen receptor levels identification were detected in qRT-PCR and Western blot assay. [BMC Molecular and Cell Biology] |
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| Reproduction had been investigated in the nematode Steinernema siamkayai, using a fermentation system supplemented with different concentrations of exogenous hexapeptides. Peptide structure-activity relationships had also been studied using prostate cancer and other mammalian cells in vitro. [PLoS One] |
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| The anti-prostate cancer of acidic exo-polysaccharide produced from marine Bacillus sp. NRC5 was determined using 7,12-dimethylbenz-(a)-anthracene (DMBA) and DMBA-induced prostate cancer in male Sprague Dawley rats. [Current Microbiology] |
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| The mode of action of progesterone on endoplasmic reticulum-associated degradation, unfolded protein response, and androgen receptor signaling in prostate cancer was investigated by cell culture studies using LNCaP and 22Rv1 cells. [Molecular Biology Reports] |
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| Researchers synthesized an aryl ester compound from quinoline-2-carboxylic acid to evaluate its apoptotic, cell cycle blockade, and antiproliferative activity on the prostate cancer cell lines (PC3). [Applied Biochemistry and Biotechnology] |
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| Preclinical prostate cancer models include standard, genetically modified and patient-derived cell lines, spheroid and organoid culture models, scaffold and hydrogel cultures, tissue slices, tumor xenograft models, patient-derived xenograft models, as well as transgenic and knockout mouse models. [Nature Reviews Urology] |
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| Cipla announced the launch of Leuprolide Acetate Injection Depot 22.5mg. The product was approved by the US FDA based on a New Drug Application submitted under the 505(b)(2) regulatory pathway. [Cipla] |
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| Dr. Pierre-Antoine Dugué was awarded the Victorian Cancer Agency Mid-Career Research Fellowship worth $681,808. The fellowships are part of an $8.5 million plan to fund new ways to detect and treat a host of cancers. [Monash University] |
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| April 23 – 28, 2023 Cancun, Mexico |
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| Indiana University School of Medicine – Bloomington, Indiana, United States |
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| Columbia University in the City of New York – New York, New York, United States |
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| STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| Imperial College London – London, England, United Kingdom |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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