| Vol. 15.02 – 20 January, 2023 |
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| The authors activated mouse T cells in vivo using acute heterologous prime–boost–boost vaccinations, transferred expanded cells to new mice, and then repeated this process iteratively over a 10 year period—greatly exceeding the mouse lifespan—and for 51 successive immunizations. [Nature] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers characterized the landscape of peripheral immune cells from patients with opioid use disorder and from healthy controls, and studied Treg-derived IFN-γ expression in murine models. [Cell] |
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| Nogo receptor 1 (NgR1) deficiency or blockade resulted in improved tumor control of NK cells by enhancing NK-to-target cell contact stability, and regulating F-actin dynamics during immunological synapse formation. [Nature Immunology] |
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| Investigators showed that invariant natural killer T (iNKT) cells were programmed predominantly with a CCR10+ skin-homing phenotype during thymic development in infant and young mice. [Nature Immunology] |
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| Researchers identified a unique subpopulation of cardiac-resident macrophages termed CD163+RETNLA+, which underwent self-renewal during sepsis and could be targeted to prevent sepsis-induced cardiomyopathy. [Nature Metabolism] |
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| Using a murine model of donor red blood cells (RBCs) expressing two distinct alloantigens, the authors demonstrated that immune priming to an intracellular antigen could directly influence alloantibody formation following exposure to a subsequent distinct surface RBC alloantigen. [Blood] |
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| Investigators demonstrated that nanoparticle-induced reactive oxygen species (ROS) were size dependent and essential for cell-mediated immunity, and they identified 50- to 60-nm nanoparticles as optimal inducers of ROS, gasdermin D activation, and T helper 1 and CD8+ responses. [Cell Reports Medicine] |
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| Scientists hypothesized that organ-specific endothelial cells may account for the differential responses to T cell-dependent bispecific antibodies (TBDs) in normal tissues and tumors, and identified a list of genes selectively upregulated by TDB in large liver vessels. [Embo Reports] |
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| Consistent with observations in human cancers, male mice showed accelerated tumor progression compared to females, but these differences were not observed in immunodeficient mice. [Cancer Research] |
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| Scientists showed that xenografting of lesional skin from psoriasis patients onto human IL-2 NOG mice resulted in increased numbers of human CD3+ cells in the grafts, axillary lymph nodes, and blood from human IL-2 NOG mice. [Plos One] |
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| The authors eview the etiology and pathophysiology of allergic diseases, including the role of the epithelial barrier, the immune system, climate change, and pollutants. [Science Translational Medicine] |
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| Investigators detail how the interaction between immune activation and an impaired barrier function of the gut is most likely a bidirectional one with alterations in the microbiota, psychological stress, and food components as upstream players in the pathophysiology of gut-brain interaction disorders. [Gut] |
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| The Phase II trial evaluated two patient populations. Dazodalibep is the only medicine in development to achieve the primary endpoint in both patient populations in a Phase II trial. [Horizon Therapeutics plc] |
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| March 19 – 21, 2023 Sitges, Spain |
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| Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| The University of Luxembourg – Belval, Luxembourg |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| University of Melbourne – Melbourne, Australia |
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| The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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