Immune Regulation News Volume 15.02 | Jan 20 2023

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    Laurisa Dohm
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    2023-01-20 | IRN 15.02


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.02 – 20 January, 2023
    TOP STORY

    Functional T Cells Are Capable of Supernumerary Cell Division and Longevity

    The authors activated mouse T cells in vivo using acute heterologous prime–boost–boost vaccinations, transferred expanded cells to new mice, and then repeated this process iteratively over a 10 year period—greatly exceeding the mouse lifespan—and for 51 successive immunizations.
    [Nature]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Opioid-Induced Fragile-Like Regulatory T Cells Contribute to Withdrawal

    Researchers characterized the landscape of peripheral immune cells from patients with opioid use disorder and from healthy controls, and studied Treg-derived IFN-γ expression in murine models.
    [Cell]

    AbstractGraphical Abstract

    NgR1 Is an NK Cell Inhibitory Receptor that Destabilizes the Immunological Synapse

    Nogo receptor 1 (NgR1) deficiency or blockade resulted in improved tumor control of NK cells by enhancing NK-to-target cell contact stability, and regulating F-actin dynamics during immunological synapse formation.
    [Nature Immunology]

    Full Article

    Developmentally Programmed Early-Age Skin Localization of iNKT Cells Supports Local Tissue Development and Homeostasis

    Investigators showed that invariant natural killer T (iNKT) cells were programmed predominantly with a CCR10+ skin-homing phenotype during thymic development in infant and young mice.
    [Nature Immunology]

    Full Article

    TREM2hi Resident Macrophages Protect the Septic Heart by Maintaining Cardiomyocyte Homeostasis

    Researchers identified a unique subpopulation of cardiac-resident macrophages termed CD163+RETNLA+, which underwent self-renewal during sepsis and could be targeted to prevent sepsis-induced cardiomyopathy.
    [Nature Metabolism]

    Full Article

    Prior Immunization to an Intracellular Antigen Enhances Subsequent Red Blood Cell Alloimmunization in Mice

    Using a murine model of donor red blood cells (RBCs) expressing two distinct alloantigens, the authors demonstrated that immune priming to an intracellular antigen could directly influence alloantibody formation following exposure to a subsequent distinct surface RBC alloantigen.
    [Blood]

    Abstract

    Non-Canonical Inflammasome Activation Mediates the Adjuvanticity of Nanoparticles

    Investigators demonstrated that nanoparticle-induced reactive oxygen species (ROS) were size dependent and essential for cell-mediated immunity, and they identified 50- to 60-nm nanoparticles as optimal inducers of ROS, gasdermin D activation, and T helper 1 and CD8+ responses.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    T Cell-Dependent Bispecific Antibodies Alter Organ-Specific Endothelial Cell–T Cell Interaction

    Scientists hypothesized that organ-specific endothelial cells may account for the differential responses to T cell-dependent bispecific antibodies (TBDs) in normal tissues and tumors, and identified a list of genes selectively upregulated by TDB in large liver vessels.
    [Embo Reports]

    Full ArticleGraphical Abstract

    Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Anti-Tumor Immunity

    Consistent with observations in human cancers, male mice showed accelerated tumor progression compared to females, but these differences were not observed in immunodeficient mice.
    [Cancer Research]

    Abstract

    Sustaining the T-Cell Activity in Xenografted Psoriasis Skin

    Scientists showed that xenografting of lesional skin from psoriasis patients onto human IL-2 NOG mice resulted in increased numbers of human CD3+ cells in the grafts, axillary lymph nodes, and blood from human IL-2 NOG mice.
    [Plos One]

    Full Article
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    REVIEWS

    Allergy: Mechanistic Insights into New Methods of Prevention and Therapy

    The authors eview the etiology and pathophysiology of allergic diseases, including the role of the epithelial barrier, the immune system, climate change, and pollutants.
    [Science Translational Medicine]

    Full Article

    Understanding Neuroimmune Interactions in Disorders of Gut–Brain Interaction: From Functional to Immune-Mediated Disorders

    Investigators detail how the interaction between immune activation and an impaired barrier function of the gut is most likely a bidirectional one with alterations in the microbiota, psychological stress, and food components as upstream players in the pathophysiology of gut-brain interaction disorders.
    [Gut]

    AbstractFull Article
    INDUSTRY AND POLICY NEWS

    Horizon Therapeutics plc Announces Phase II Trial Evaluating Dazodalibep for the Treatment of Sjögren’s Syndrome Meets Primary Endpoint in the Second Study Population

    The Phase II trial evaluated two patient populations. Dazodalibep is the only medicine in development to achieve the primary endpoint in both patient populations in a Phase II trial.
    [Horizon Therapeutics plc]

    Press Release
    FEATURED EVENT

    Cell Symposium: Viruses in Health and Disease

    March 19 – 21, 2023
    Sitges, Spain

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Liver Organoids

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Lab Technician – CRISPR-Cas9 in Neuroimmunology

    The University of Luxembourg – Belval, Luxembourg

    Sheila Joan Smith Professorship – Immunology

    University of Cambridge – Cambridge, England, United Kingdom

    PhD position – Glial-Immune Interactions

    University of Melbourne – Melbourne, Australia

    Research Chair – Immunology

    The University of Edinburgh – Edinburgh, Scotland, United Kingdom

    > See All Jobs

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