| Vol. 7.05 – 10 February, 2023 |
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| Scientists integrated single-nucleus transcriptomics and epigenomics to characterize all major liver cell types during NASH development in mice and humans. [Science Translational Medicine] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that acute liver damage in the setting of targeted SRSF1 deletion in mice was associated with the excessive formation of deleterious RNA–DNA hybrids, which induced DNA damage. [Nature Communications] |
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| The authors demonstrated increased liver CCL2 expression in patients with NASH, and commensurately, a 100-fold increase in hepatocyte Ccl2 expression in a mouse model of NASH, accompanied by increased liver monocyte-derived macrophage infiltrate and liver fibrosis. [JCI Insight] |
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| Scientists determined the roles of hypoxia-associated circRNAs in immune escape of HCC cells. [Experimental Hematology & Oncology] |
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| Investigators examined whether the administration of young and undamaged recombinant albumin could alleviate type 2 diabetes mellitus in mice. [Journal of Translational Medicine] |
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| Researchers explored the key genes involved in HCC when exposure to 2,3,7,8-tet-rachlorodibenzo-p-dioxin and α-endosulfan by weighted gene co-expression network analysis. [Ecotoxicology And Environmental Safety] |
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| The authors reported that PD-L1 regulated not only the epithelial–mesenchymal transition, but also the stem-like transition in liver cancer cells. They observed high PD-L1 expression in CD133+ liver cancer stem cells (CSCs) and CSC-enriched tumorspheres. [Cancer Science] |
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| Investigators reported that the haploinsufficient tumour suppressor ASPP2, could inhibit HCC growth and stemness characteristics by regulating the Warburg effect through the WNT/β-catenin pathway. [Journal Of Cellular And Molecular Medicine] |
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| The authors demonstrated that miR-22 indirectly regulated SPRY2 by inhibiting CBL, an E3 ligase for SPRY2 that has been confirmed. [PLOS One] |
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| Investigators comprehensively review the role and mechanisms of autophagy in HCC and discuss the potential benefit of targeting this process in the treatment of the cancer. [Cell Communication and Signaling] |
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| Sunshine Biopharma, Inc. announced the signing of a research agreement with Sir Mortimer B. Davis Jewish General Hospital, a McGill University Health Center hospital, to be focused on advancing the development of Sunshine Biopharma’s Adva-27a anticancer compound through the IND-enabling studies. [Sunshine Biopharma (Financial Post)] |
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| April 23 – 28, 2023 Cancun, Mexico |
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| University of Alberta – Edmonton, Alberta, Canada |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Mississippi Medical Center – Jackson, Mississippi, United States |
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| University of Illinois Chicago – Chicago, Illinois, United States |
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| UNC-Greensboro – Kannapolis, North Carolina, United States |
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