Hepatic Cell News Volume 7.05 | Feb 10 2023

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    2023-02-10 | HCN 7.05


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.05 – 10 February, 2023
    TOP STORY

    Hepatocytes Demarcated by EphB2 Contribute to the Progression of Nonalcoholic Steatohepatitis

    Scientists integrated single-nucleus transcriptomics and epigenomics to characterize all major liver cell types during NASH development in mice and humans.
    [Science Translational Medicine]

    Abstract
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    Splicing Factor SRSF1 Deficiency in the Liver Triggers NASH-Like Pathology and Cell Death

    Researchers showed that acute liver damage in the setting of targeted SRSF1 deletion in mice was associated with the excessive formation of deleterious RNA–DNA hybrids, which induced DNA damage.
    [Nature Communications]

    Full Article

    Notch-Mediated Hepatocyte MCP-1 Secretion Causes Liver Fibrosis

    The authors demonstrated increased liver CCL2 expression in patients with NASH, and commensurately, a 100-fold increase in hepatocyte Ccl2 expression in a mouse model of NASH, accompanied by increased liver monocyte-derived macrophage infiltrate and liver fibrosis.
    [JCI Insight]

    Full ArticleGraphical Abstract

    Hypoxia-Associated circPRDM4 Promotes Immune Escape via HIF-1α Regulation of PD-L1 in Hepatocellular Carcinoma

    Scientists determined the roles of hypoxia-associated circRNAs in immune escape of HCC cells.
    [Experimental Hematology & Oncology]

    Full Article

    Young and Undamaged Recombinant Albumin Alleviates T2DM by Improving Hepatic Glycolysis through EGFR and Protecting Islet β Cells in Mice

    Investigators examined whether the administration of young and undamaged recombinant albumin could alleviate type 2 diabetes mellitus in mice.
    [Journal of Translational Medicine]

    Full Article

    Identification of Key Genes in Hepatocellular Carcinoma Associated with Exposure to TCDD and α-Endosulfan by WGCNA

    Researchers explored the key genes involved in HCC when exposure to 2,3,7,8-tet-rachlorodibenzo-p-dioxin and α-endosulfan by weighted gene co-expression network analysis.
    [Ecotoxicology And Environmental Safety]

    Full ArticleGraphical Abstract

    PD-L1 Regulates Epithelial–Mesenchymal Transition and Cancer Stem Cell Phenotypes in Hepatocellular Carcinoma through SGK2/β-Catenin Signaling Pathway

    The authors reported that PD-L1 regulated not only the epithelial–mesenchymal transition, but also the stem-like transition in liver cancer cells. They observed high PD-L1 expression in CD133+ liver cancer stem cells (CSCs) and CSC-enriched tumorspheres.
    [Cancer Science]

    Abstract

    ASPP2 Suppresses Tumor Growth and Stemness Characteristics in HCC by Inhibiting Warburg Effect via WNT/β-Catenin/HK2 Axis

    Investigators reported that the haploinsufficient tumour suppressor ASPP2, could inhibit HCC growth and stemness characteristics by regulating the Warburg effect through the WNT/β-catenin pathway.
    [Journal Of Cellular And Molecular Medicine]

    Full Article

    Hsa-miR-22-3p Inhibits Liver Cancer Cell EMT and Cell Migration/Invasion by Indirectly Regulating SPRY2

    The authors demonstrated that miR-22 indirectly regulated SPRY2 by inhibiting CBL, an E3 ligase for SPRY2 that has been confirmed.
    [PLOS One]

    Full Article
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    REVIEWS

    Targeting and Regulation of Autophagy in Hepatocellular Carcinoma: Revisiting the Molecular Interactions and Mechanisms for New Therapy Approaches

    Investigators comprehensively review the role and mechanisms of autophagy in HCC and discuss the potential benefit of targeting this process in the treatment of the cancer.
    [Cell Communication and Signaling]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Sunshine Biopharma Signs Research Agreement With the Jewish General Hospital to Advance the Development of Adva-27a Anticancer Compound

    Sunshine Biopharma, Inc. announced the signing of a research agreement with Sir Mortimer B. Davis Jewish General Hospital, a McGill University Health Center hospital, to be focused on advancing the development of Sunshine Biopharma’s Adva-27a anticancer compound through the IND-enabling studies.
    [Sunshine Biopharma (Financial Post)]

    Press Release
    FEATURED EVENT

    Cell Culture Engineering XVIII

    April 23 – 28, 2023
    Cancun, Mexico

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    JOB OPPORTUNITIES

    Academic Position – Hepatology

    University of Alberta – Edmonton, Alberta, Canada

    Postdoctoral Associate – Liver Disease

    Baylor College of Medicine – Houston, Texas, United States

    Associate Professor – Department of Cell and Molecular Biology

    University of Mississippi Medical Center – Jackson, Mississippi, United States

    Postdoctoral Fellow – Liver Diseases

    University of Illinois Chicago – Chicago, Illinois, United States

    Postdoctoral Fellow – Alcohol-Associated Liver Disease

    UNC-Greensboro – Kannapolis, North Carolina, United States

    > See All Jobs

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