| Vol. 7.07 – 24 February, 2023 |
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| The authors used human fetal hepatocyte organoids to model the first stage of nonalcoholic fatty liver disease, steatosis, representing three different triggers: free fatty acid loading, interindividual genetic variability, and monogenic lipid disorders. [Nature Biotechnology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Using integrative metabolomics and transcriptomics analyses, investigators showed heterogeneity between metabolite and transcript profiles in HCC. [Nature Communications] |
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| Researchers investigated the role of FGF12 in the regulation of liver fibrosis. Expression of FGF12 was up‐regulated in nonparenchymal liver cells, especially in hepatic macrophages. [Hepatology] |
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| Scientists determined how hepatic stellate cell‐targeting lipocalin‐2 mediated the transition from simple steatosis to nonalcoholic steatohepatitis. [Hepatology] |
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| Investigators showed that liver clock genes, especially nuclear receptor subfamily 1 group d member 1 (NR1D1), were dysregulated in mice with carbon tetrachloride-induced liver fibrosis. [Pharmacological Research] |
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| The Cancer Genome Atlas Liver Hepatocellular Carcinoma database showed that the number of G protein subunit alpha i2 transcripts in HCC tissues was significantly higher than that in the normal liver tissues. [Cell Death & Disease] |
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| The level of hepatic forkhead box protein A2 (FOXA2) expression was found to be lower in HCC tissues than in paired adjacent tumor tissues. A low level of FOXA2 expression was associated with aggressive tumor characteristics. [BioScience Trends] |
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| Hepatic stellate cells (HSCs) cell lines and primary HSC were cultured and functionally scientists found that gomisin D promoted HSC apoptosis, and inhibited HSC activation and proliferation. [International Journal of Biological Macromolecules] |
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| The authors investigated the role of hepatic autophagy, a cellular survival pathway, in cholestatic liver injury driven by a hepatotoxin. [Cell Death Discovery] |
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| Scientists examine the role of mesenchymal stromal cells in the pathogenesis and treatment of hepatic fibrosis/cirrhosis. [Cellular & Molecular Immunology] |
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| The money had been earmarked for UK involvement in the EU’s Horizon Europe €100bn research program. The funds have not been spent because the UK’s association with the program has been held up by the dispute over the Northern Ireland Protocol. [BBC News] |
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| April 23 – 28, 2023 Cancun, Mexico |
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| Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| Cornell University – Ithaca, New York, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| The Henry Ford Health System – Detroit, Michigan, United States |
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| Twincore GmbH – Hannover, Germany |
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