Hepatic Cell News Volume 7.07 | Feb 24 2023

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    2023-02-24 | HCN 7.07


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.07 – 24 February, 2023
    TOP STORY

    Engineered Human Hepatocyte Organoids Enable CRISPR-Based Target Discovery and Drug Screening for Steatosis

    The authors used human fetal hepatocyte organoids to model the first stage of nonalcoholic fatty liver disease, steatosis, representing three different triggers: free fatty acid loading, interindividual genetic variability, and monogenic lipid disorders.
    [Nature Biotechnology]

    Full ArticlePress Release
    Free Wallchart: Dynamic Modeling in Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    PHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma

    Using integrative metabolomics and transcriptomics analyses, investigators showed heterogeneity between metabolite and transcript profiles in HCC.
    [Nature Communications]

    Full Article

    Macrophage-Specific FGF12 Promotes Liver Fibrosis Progression in Mice

    Researchers investigated the role of FGF12 in the regulation of liver fibrosis. Expression of FGF12 was up‐regulated in nonparenchymal liver cells, especially in hepatic macrophages.
    [Hepatology]

    AbstractGraphical Abstract

    Lipocalin-2 Activates Hepatic Stellate Cells and Promotes Nonalcoholic Steatohepatitis in High-Fat Diet–Fed Ob/Ob Mice

    Scientists determined how hepatic stellate cell‐targeting lipocalin‐2 mediated the transition from simple steatosis to nonalcoholic steatohepatitis.
    [Hepatology]

    Full ArticleGraphical Abstract

    m6A Methylation-Induced NR1D1 Ablation Disrupts the HSC Circadian Clock and Promotes Hepatic Fibrosis

    Investigators showed that liver clock genes, especially nuclear receptor subfamily 1 group d member 1 (NR1D1), were dysregulated in mice with carbon tetrachloride-induced liver fibrosis.
    [Pharmacological Research]

    Full ArticleGraphical Abstract

    Identification of G Protein Subunit Alpha i2 as a Promising Therapeutic Target of Hepatocellular Carcinoma

    The Cancer Genome Atlas Liver Hepatocellular Carcinoma database showed that the number of G protein subunit alpha i2 transcripts in HCC tissues was significantly higher than that in the normal liver tissues.
    [Cell Death & Disease]

    Full Article

    FOXA2 Plays a Critical Role in Hepatocellular Carcinoma Progression and Lenvatinib-Associated Drug Resistance

    The level of hepatic forkhead box protein A2 (FOXA2) expression was found to be lower in HCC tissues than in paired adjacent tumor tissues. A low level of FOXA2 expression was associated with aggressive tumor characteristics.
    [BioScience Trends]

    Abstract

    Gomisin D Alleviates Liver Fibrosis through Targeting PDGFRβ in Hepatic Stellate Cells

    Hepatic stellate cells (HSCs) cell lines and primary HSC were cultured and functionally scientists found that gomisin D promoted HSC apoptosis, and inhibited HSC activation and proliferation.
    [International Journal of Biological Macromolecules]

    Full Article

    Impaired Hepatic Autophagy Exacerbates Hepatotoxin Induced Liver Injury

    The authors investigated the role of hepatic autophagy, a cellular survival pathway, in cholestatic liver injury driven by a hepatotoxin.
    [Cell Death Discovery]

    Full Article
    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    REVIEWS

    Mesenchymal Stromal Cells in Hepatic Fibrosis/Cirrhosis: From Pathogenesis to Treatment

    Scientists examine the role of mesenchymal stromal cells in the pathogenesis and treatment of hepatic fibrosis/cirrhosis.
    [Cellular & Molecular Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Treasury Takes Back £1.6Bn Promised for Science

    The money had been earmarked for UK involvement in the EU’s Horizon Europe €100bn research program. The funds have not been spent because the UK’s association with the program has been held up by the dispute over the Northern Ireland Protocol.
    [BBC News]

    Press Release
    FEATURED EVENT

    Cell Culture Engineering XVIII

    April 23 – 28, 2023
    Cancun, Mexico

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Chronic Liver Disease

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Laboratory Technician – Flyak Lab

    Cornell University – Ithaca, New York, United States

    Senior Staff Scientist – Mass Spectrometry

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Fellow – Cancer Biology

    The Henry Ford Health System – Detroit, Michigan, United States

    Postdoctoral Position – Hepatitis C Virus Vaccine Research

    Twincore GmbH – Hannover, Germany

    > See All Jobs

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