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Vol. 11.10 – 21 March, 2023
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Delivery of mRNA encoding a laboratory-evolved adenine base editing and guide RNA into a CD3δ severe combined immunodeficiency patient’s hematopoietic stem and progenitor cells resulted in a 71.2% ± 7.85% correction of the pathogenic mutation.
[Cell]
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PUBLICATIONSRanked by the impact factor of the journal
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To investigate the immunobiology of ER+ breast cancer in women with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC), scientists performed phenotypic, transcriptional, and functional analyses for a cohort of treatment-naive IDC and ILC tumors.
[Nature Cancer]
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Researchers comprehensively profiled the genomic occupancy of mSWI/SNF chromatin remodeling complexes throughout acute and chronic T cell stimulation.
[Molecular Cell]
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Investigators showed the immune subset composition of the human fetal intestine during development, by longitudinal spectral flow cytometry analysis of samples between 14 and 22 weeks of gestation.
[Nature Communications]
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The authors reported on a heterozygous interferon regulatory factor 4 (IRF4) missense variant identified in three patients from a multigeneration family with hypogammaglobulinemia, characterizing the immunological consequences of this neomorphic mutation.
[Journal Of Experimental Medicine]
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Patients with stage III melanoma and high intra-tumoral interferon-γ (IFN-γ) scores were randomized to neoadjuvant nivolumab or nivolumab + domatinostat, while patients with low IFN-γ scores received nivolumab + domatinostat or ipilimumab + nivolumab + domatinostat.
[Journal Of Experimental Medicine]
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Scientists applied a systems approach to profile hemagglutinin- and neuraminidase-specific humoral signatures that track with the evolution of broad immunity in a cohort of vaccinated individuals and validated these findings in a second longitudinal cohort.
[Cell Reports Medicine]
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Researchers targeted a regulatory axis of T cell inflammatory responses, Regnase-1 and Roquin-1, to enhance antitumor responses in human T cells engineered with two clinical-stage immune receptors.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
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In overt human B-cell malignancies, knockdown of the long plus intermediate isoforms of the PRL receptor (LF/IFPRLR) reduced B-cell viability and their MYC and BCL2 expression, and reduced the growth of human B-cell malignancies in vitro and in vivo.
[Communications Biology]
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Scientists review studies describing the connection between clonal hematopoiesis (CH) and pathological immune dysfunction, the effects of CH-associated genetic alterations on the function of myeloid and lymphoid cells, and the clinical and therapeutic implications of CH as a target for immunomodulation.
[Nature Reviews Immunology]
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The authors summarize our current understanding of tumor-infiltrating lymphocyte-B cells and plasma cells in human cancer, highlighting the compelling therapeutic opportunities offered by their unique tumor recognition and effector mechanisms.
[Cancer Cell]
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BioNTech and OncoC4 are partnering up to develop and commercialize OncoC4’s anti-CTLA-4 monoclonal antibody candidate, ONC-392, as a monotherapy or combination therapy for various cancers.
[Gene Online (OncoC4)]
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April 23 – 26, 2023
Snowbird, Utah, United States
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Pfizer, Inc. – Any North American Pfizer Site
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Rutgers New Jersey Medical School – Newark, New Jersey, United States
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Oslo University Hospital – Oslo, Norway
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Ume̴ University РUme̴, Sweden
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University Hospital Duesseldorf – Düsseldorf, Germany
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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Pulmonary Cell News