 | | Vol. 11.10 – 21 March, 2023 |
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| Delivery of mRNA encoding a laboratory-evolved adenine base editing and guide RNA into a CD3δ severe combined immunodeficiency patient’s hematopoietic stem and progenitor cells resulted in a 71.2% ± 7.85% correction of the pathogenic mutation.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To investigate the immunobiology of ER+ breast cancer in women with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC), scientists performed phenotypic, transcriptional, and functional analyses for a cohort of treatment-naive IDC and ILC tumors.
[Nature Cancer] |
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| Researchers comprehensively profiled the genomic occupancy of mSWI/SNF chromatin remodeling complexes throughout acute and chronic T cell stimulation.
[Molecular Cell] |
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| Investigators showed the immune subset composition of the human fetal intestine during development, by longitudinal spectral flow cytometry analysis of samples between 14 and 22 weeks of gestation.
[Nature Communications] |
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| The authors reported on a heterozygous interferon regulatory factor 4 (IRF4) missense variant identified in three patients from a multigeneration family with hypogammaglobulinemia, characterizing the immunological consequences of this neomorphic mutation.
[Journal Of Experimental Medicine] |
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| Patients with stage III melanoma and high intra-tumoral interferon-γ (IFN-γ) scores were randomized to neoadjuvant nivolumab or nivolumab + domatinostat, while patients with low IFN-γ scores received nivolumab + domatinostat or ipilimumab + nivolumab + domatinostat.
[Journal Of Experimental Medicine] |
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| Scientists applied a systems approach to profile hemagglutinin- and neuraminidase-specific humoral signatures that track with the evolution of broad immunity in a cohort of vaccinated individuals and validated these findings in a second longitudinal cohort.
[Cell Reports Medicine] |
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| Researchers targeted a regulatory axis of T cell inflammatory responses, Regnase-1 and Roquin-1, to enhance antitumor responses in human T cells engineered with two clinical-stage immune receptors.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| In overt human B-cell malignancies, knockdown of the long plus intermediate isoforms of the PRL receptor (LF/IFPRLR) reduced B-cell viability and their MYC and BCL2 expression, and reduced the growth of human B-cell malignancies in vitro and in vivo.
[Communications Biology] |
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| Scientists review studies describing the connection between clonal hematopoiesis (CH) and pathological immune dysfunction, the effects of CH-associated genetic alterations on the function of myeloid and lymphoid cells, and the clinical and therapeutic implications of CH as a target for immunomodulation.
[Nature Reviews Immunology] |
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| The authors summarize our current understanding of tumor-infiltrating lymphocyte-B cells and plasma cells in human cancer, highlighting the compelling therapeutic opportunities offered by their unique tumor recognition and effector mechanisms.
[Cancer Cell] |
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| BioNTech and OncoC4 are partnering up to develop and commercialize OncoC4’s anti-CTLA-4 monoclonal antibody candidate, ONC-392, as a monotherapy or combination therapy for various cancers.
[Gene Online (OncoC4)] |
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| April 23 – 26, 2023
Snowbird, Utah, United States |
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| | Pfizer, Inc. – Any North American Pfizer Site |
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| | Rutgers New Jersey Medical School – Newark, New Jersey, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Umeå University – Umeå, Sweden |
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| | University Hospital Duesseldorf – Düsseldorf, Germany |
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