 | | Vol. 7.13 – 21 April, 2023 |
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| The progression of HCC was robustly mitigated by thymidine kinase 1 (TK1) knockdown and significantly aggravated by its overexpression. Furthermore, TK1 promoted the oncogenic phenotypes of HCC not only through its enzymatic activity but also by promoting glycolysis.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A targeted therapeutic strategy is presented for potentiating tumor vascular normalization and systematic chemo-immunotherapy to effectively inhibit the progression of hepatocellular carcinoma (HCC) in both orthotopic model and patients-derived organoids.
[Small] |
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| Investigators demonstrated that abnormal lipid accumulation in transplanted human hepatocytes was associated with compromised interleukin-6 (IL-6)–glycoprotein 130 (GP130) signaling in human hepatocytes because of incompatibility between host IL-6 and IL-6 receptors on donor hepatocytes.
[Science Advances] |
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| Researchers investigated the potential dysregulation of tumor necrosis factor receptor-associated factor 2 (TRAF2) and its biological function in liver cancer, and elucidated the underlying mechanism, leading to the validation of TRAF2 as an attractive liver cancer target.
[Cell Death & Differentiation] |
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| Investigators demonstrated that DNA methylation suppressed RIPK3 expression in human hepatocytes and HepG2 cells.
[Cell Death & Differentiation] |
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| Scientists designed and implemented a novel strategy that allows the generation of an unlimited source of clonal, homogeneous, non-transformed induced hepatocyte-like cells, capable of performing typical hepatic functions and suitable for pharmaco-toxicological high-throughput testing.
[Stem Cell Research & Therapy] |
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| Researchers developed a multifocal HCC model to test immunotherapies by introducing c-myc using hydrodynamic gene transfer along with CRISPR-Cas9-mediated disruption of p53 in mouse hepatocytes.
[iScience] |
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| Investigators showed that mesenchymal stem cell-derived exosomes as an anti-inflammatory agent in combination with metformin could increase the therapeutic efficacy of metformin without needing to change metformin doses by decreasing inflammatory cytokines production in HepG2 cells.
[Heliyon] |
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| To identify mesenchymal stem cells that were most suitable for hepatic differentiation and treatment of liver failure, scientists used a three-phase induction process in which human adipose-derived stem cells and umbilical cord mesenchymal stem cells were induced to differentiate towards hepatocyte-like cells in vitro.
[Acta Biochimica Et Biophysica Sinica] |
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| Researchers suggested absent in melanoma 2 (AIM2) played an inhibitory role in regulating the growth and metastasis of HCC, which supported the notion that AIM2 could serve as a potential therapeutic target for HCC.
[Pathology Research And Practice] |
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| The authors examine studies delineating the relationship between endocannabinoids and HCC. Based on collected findings, detailed studies of the molecular mechanism of endocannabinoids as well as preclinical studies for investigating therapeutic or carcinogenic impacts in HCC cancer are strongly suggested.
[Environmental Research] |
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| Genentech announced new data from the Phase III IMbrave050 study that show Tecentriq® plus Avastin® demonstrated a statistically significant improvement in recurrence-free survival in people with HCC at high risk of disease recurrence following liver resection or ablation with curative intent.
[Genentech] |
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| April 30 – May 5, 2023
Barga, Italy |
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| | University of Reading – Reading, England, United Kingdom |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | The Beckman Research Institute of City of Hope – Duarte, California, United States |
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