Hepatic Cell News Volume 7.13 | Apr 21 2023

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    2023-04-21 | HCN 7.13


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.13 – 21 April, 2023
    TOP STORY

    Thymidine Kinase 1 Drives Hepatocellular Carcinoma in Enzyme-Dependent and -Independent Manners

    The progression of HCC was robustly mitigated by thymidine kinase 1 (TK1) knockdown and significantly aggravated by its overexpression. Furthermore, TK1 promoted the oncogenic phenotypes of HCC not only through its enzymatic activity but also by promoting glycolysis.
    [Cell Metabolism]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Normalization of Tumor Vessels by Lenvatinib-Based Metallo-Nanodrugs Alleviates Hypoxia and Enhances Calreticulin-Mediated Immune Responses in Orthotopic HCC and Organoids

    A targeted therapeutic strategy is presented for potentiating tumor vascular normalization and systematic chemo-immunotherapy to effectively inhibit the progression of hepatocellular carcinoma (HCC) in both orthotopic model and patients-derived organoids.
    [Small]

    Abstract

    IL-6–GP130 Signaling Protects Human Hepatocytes against Lipid Droplet Accumulation in Humanized Liver Models

    Investigators demonstrated that abnormal lipid accumulation in transplanted human hepatocytes was associated with compromised interleukin-6 (IL-6)–glycoprotein 130 (GP130) signaling in human hepatocytes because of incompatibility between host IL-6 and IL-6 receptors on donor hepatocytes.
    [Science Advances]

    Full Article

    The TRAF2-p62 Axis Promotes Proliferation and Survival of Liver Cancer by Activating mTORC1 Pathway

    Researchers investigated the potential dysregulation of tumor necrosis factor receptor-associated factor 2 (TRAF2) and its biological function in liver cancer, and elucidated the underlying mechanism, leading to the validation of TRAF2 as an attractive liver cancer target.
    [Cell Death & Differentiation]

    Full Article

    RIPK3 Promoter Hypermethylation in Hepatocytes Protects from Bile Acid-Induced Inflammation and Necroptosis

    Investigators demonstrated that DNA methylation suppressed RIPK3 expression in human hepatocytes and HepG2 cells.
    [Cell Death & Differentiation]

    Full ArticleGraphical Abstract

    A Robust Reprogramming Strategy for Generating Hepatocyte-Like Cells Usable in Pharmaco-Toxicological Studies

    Scientists designed and implemented a novel strategy that allows the generation of an unlimited source of clonal, homogeneous, non-transformed induced hepatocyte-like cells, capable of performing typical hepatic functions and suitable for pharmaco-toxicological high-throughput testing.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    Expansion of Macrophage and Liver Sinusoidal Endothelial Cell Subpopulations during Non-Alcoholic Steatohepatitis Progression

    Researchers developed a multifocal HCC model to test immunotherapies by introducing c-myc using hydrodynamic gene transfer along with CRISPR-Cas9-mediated disruption of p53 in mouse hepatocytes.
    [iScience]

    Full ArticleGraphical Abstract

    Combinational Administration of Mesenchymal Stem Cell-Derived Exosomes and Metformin Reduces Inflammatory Responses in an In Vitro Model of Insulin Resistance in HepG2 Cells

    Investigators showed that mesenchymal stem cell-derived exosomes as an anti-inflammatory agent in combination with metformin could increase the therapeutic efficacy of metformin without needing to change metformin doses by decreasing inflammatory cytokines production in HepG2 cells.
    [Heliyon]

    Full ArticleGraphical Abstract

    Adipose-Derived Stem Cells Show Hepatic Differentiation Potential and Therapeutic Effect in Rats with Acute Liver Failure

    To identify mesenchymal stem cells that were most suitable for hepatic differentiation and treatment of liver failure, scientists used a three-phase induction process in which human adipose-derived stem cells and umbilical cord mesenchymal stem cells were induced to differentiate towards hepatocyte-like cells in vitro.
    [Acta Biochimica Et Biophysica Sinica]

    Full Article

    The Role of AIM2 in Human Hepatocellular Carcinoma and Its Clinical Significance

    Researchers suggested absent in melanoma 2 (AIM2) played an inhibitory role in regulating the growth and metastasis of HCC, which supported the notion that AIM2 could serve as a potential therapeutic target for HCC.
    [Pathology Research And Practice]

    Abstract
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    REVIEWS

    The Endocannabinoid System, a New Gatekeeper in the Pharmacology of Human Hepatocellular Carcinoma

    The authors examine studies delineating the relationship between endocannabinoids and HCC. Based on collected findings, detailed studies of the molecular mechanism of endocannabinoids as well as preclinical studies for investigating therapeutic or carcinogenic impacts in HCC cancer are strongly suggested.
    [Environmental Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Genentech’s Tecentriq plus Avastin Reduced the Risk of Cancer Returning in People with Certain Types of Adjuvant Liver Cancer in a Phase III Study

    Genentech announced new data from the Phase III IMbrave050 study that show Tecentriq® plus Avastin® demonstrated a statistically significant improvement in recurrence-free survival in people with HCC at high risk of disease recurrence following liver resection or ablation with curative intent.
    [Genentech]

    Press Release
    FEATURED EVENT

    Understanding Cell Behavior and Communication

    April 30 – May 5, 2023
    Barga, Italy

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    JOB OPPORTUNITIES

    Postdoctoral Studentship – Platelet Function in Liver Disease

    University of Reading – Reading, England, United Kingdom

    Postdoctoral Research Associate – Head and Neck Cancer

    University of Liverpool – Liverpool, England, United Kingdom

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Postdoctoral Research Fellow – Striated Muscle Biology

    Cincinnati Children’s Hospital – Cincinnati, Ohio, United States

    Postdoctoral Fellow – Herpesvirus Vaccine Development

    The Beckman Research Institute of City of Hope – Duarte, California, United States

    > See All Jobs

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