Hepatocyte Dedifferentiation Profiling in Alcohol-Related Liver Disease Identifies CXCR4 as a Driver of Cell Reprogramming

Researchers described that hepatocyte dedifferentiation was associated with disease severity and a reduced synthetic capacity of the liver. Moreover, they identify the CXCR4 pathway as a driver of hepatocyte dedifferentiation and as a therapeutic target in alcohol-related hepatitis.