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| Scientists identified tumor-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumur EVP secretion via depletion of Rab27a. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In SIRT2-deficient hepatocytes, leucine-rich α-2-glycoprotein 1 (LRG1) levels in small extracellular vesicles were upregulated, leading to increased transfer of LRG1 to bone-marrow-derived monocytes, and in turn, to inhibition of osteoclast differentiation. [Nature Metabolism] |
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| Mechanistically, pituitary tumor transforming gene 1 (PTTG1) promoted asparagine synthetase transcription by binding to its promoter, and asparagine levels were correspondingly increased, which subsequently activated the mTOR pathway to facilitate HCC progression. [Cancer Research] |
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| Polyphyllin D-enhanced lysosomal membrane permeabilization to release sorafenib, augmenting the anticancer effect of sorafenib both in vivo and in vitro. [Molecular Therapy] |
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| Hepatocyte-specific deletion of Foxk1 in mice fed a NASH-inducing diet ameliorated not only hepatic steatosis, but also associated inflammation, fibrosis, and tumorigenesis, resulting in improved survival. [Cell Reports] |
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| The authors provided a droplet-based and layer-by-layer 3D bioprinting strategy for in vitro construction of liver organoids with biomimetic lobule structure. [Cell Proliferation] |
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| Experiments showed that β-arrestin2 deficiency attenuated TNF-α-induced primary hepatocyte apoptosis by activating the Akt/GSK-3β pathway. [Acta Pharmacologica Sinica] |
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| Researchers found that hexokinase domain-containing-1 (HKDC1) overexpression, over time, caused impaired glucose homeostasis in male mice and shifted glucose metabolism towards anabolic pathways with an increase in nucleotide synthesis. [Scientific Reports] |
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| Co-incubation of TGF-β1-induced hepatic stellate cell-T6 cells with lymphocyte-specific protein tyrosine kinase-siRNA inhibited cell proliferation and activation. [Inflammation] |
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| The authors discuss the emergence of hepatic parenchymal and non-parenchymal cells, advances that have been made in in vitro modeling of liver development and draw parallels between developmental and pathological processes. [Nature Reviews Gastroenterology & Hepatology] |
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| Scientists summarize the functional importance, molecular mechanism, and clinical application of protein glycosylation alterations in HCC. [Oncogene] |
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| Hepion Pharmaceuticals, Inc. announced positive topline results from its recently completed Phase II ALTITUDE-NASH clinical trial by demonstrating improved physiologic liver function and was well tolerated after four months of treatment in subjects with stage 3 or greater fibrosis based on the AGILE 3+ criteria. [Hepion Pharamceutricals] |
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| June 18 – 22, 2023 Keystone, Colorado, United States |
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| Karolinska Institutet – Stockholm, Sweden |
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| Baylor College of Medicine, Texas, United States |
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| Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| Helmholtz Association of German Research Centres – Heidelberg, Germany |
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| University of Utah – Salt Lake City, Utah, United States |
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