Hepatic Cell News Volume 7.18 | May 26 2023

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    Laurisa Dohm
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    2023-05-26 | HCN 7.18


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.18 – 26 May, 2023
    TOP STORY

    Tumor Extracellular Vesicles and Particles Induce Liver Metabolic Dysfunction

    Scientists identified tumor-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumur EVP secretion via depletion of Rab27a.
    [Nature]

    Abstract
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    PUBLICATIONSRanked by the impact factor of the journal

    SIRT2 Regulates Extracellular Vesicle-Mediated Liver–Bone Communication

    In SIRT2-deficient hepatocytes, leucine-rich α-2-glycoprotein 1 (LRG1) levels in small extracellular vesicles were upregulated, leading to increased transfer of LRG1 to bone-marrow-derived monocytes, and in turn, to inhibition of osteoclast differentiation.
    [Nature Metabolism]

    Full Article

    PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression

    Mechanistically, pituitary tumor transforming gene 1 (PTTG1) promoted asparagine synthetase transcription by binding to its promoter, and asparagine levels were correspondingly increased, which subsequently activated the mTOR pathway to facilitate HCC progression.
    [Cancer Research]

    Abstract

    Polyphyllin D “Punctures” Hypertrophic Lysosomes to Reverse Drug Resistance of Hepatocellular Carcinoma by Targeting Acid Sphingomyelinase

    Polyphyllin D-enhanced lysosomal membrane permeabilization to release sorafenib, augmenting the anticancer effect of sorafenib both in vivo and in vitro.
    [Molecular Therapy]

    AbstractGraphical Abstract

    FOXK1 Promotes Nonalcoholic Fatty Liver Disease by Mediating mTORC1-Dependent Inhibition of Hepatic Fatty Acid Oxidation

    Hepatocyte-specific deletion of Foxk1 in mice fed a NASH-inducing diet ameliorated not only hepatic steatosis, but also associated inflammation, fibrosis, and tumorigenesis, resulting in improved survival.
    [Cell Reports]

    Full ArticleGraphical Abstract

    In Vitro Construction of Liver Organoids with Biomimetic Lobule Structure by a Multicellular 3D Bioprinting Strategy

    The authors provided a droplet-based and layer-by-layer 3D bioprinting strategy for in vitro construction of liver organoids with biomimetic lobule structure.
    [Cell Proliferation]

    Full Article

    β-arrestin2 Deficiency Ameliorates S-100-Induced Autoimmune Hepatitis in Mice by Inhibiting Infiltration of Monocyte-Derived Macrophage and Attenuating Hepatocyte Apoptosis

    Experiments showed that β-arrestin2 deficiency attenuated TNF-α-induced primary hepatocyte apoptosis by activating the Akt/GSK-3β pathway.
    [Acta Pharmacologica Sinica]

    Full Article

    Liver-Specific Overexpression of HKDC1 Increases Hepatocyte Size and Proliferative Capacity

    Researchers found that hexokinase domain-containing-1 (HKDC1) overexpression, over time, caused impaired glucose homeostasis in male mice and shifted glucose metabolism towards anabolic pathways with an increase in nucleotide synthesis.
    [Scientific Reports]

    Full Article

    Lymphocyte-Specific Protein Tyrosine Kinase Contributes to Spontaneous Regression of Liver Fibrosis by Interacting with Suppressor of Cytokine Signaling 1

    Co-incubation of TGF-β1-induced hepatic stellate cell-T6 cells with lymphocyte-specific protein tyrosine kinase-siRNA inhibited cell proliferation and activation.
    [Inflammation]

    Abstract
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    REVIEWS

    Fetal Liver Development and Implications for Liver Disease Pathogenesis

    The authors discuss the emergence of hepatic parenchymal and non-parenchymal cells, advances that have been made in in vitro modeling of liver development and draw parallels between developmental and pathological processes.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    Protein Glycosylation Alterations in Hepatocellular Carcinoma: Function and Clinical Implications

    Scientists summarize the functional importance, molecular mechanism, and clinical application of protein glycosylation alterations in HCC.
    [Oncogene]

    Full Article
    INDUSTRY AND POLICY NEWS

    Hepion Pharmaceuticals’ Phase II ‘ALTITUDE-NASH’ Trial Achieves Primary and Secondary Endpoints, Including Improvement in Liver Function and Multiple NASH Biomarkers

    Hepion Pharmaceuticals, Inc. announced positive topline results from its recently completed Phase II ALTITUDE-NASH clinical trial by demonstrating improved physiologic liver function and was well tolerated after four months of treatment in subjects with stage 3 or greater fibrosis based on the AGILE 3+ criteria.
    [Hepion Pharamceutricals]

    Press Release
    FEATURED EVENT

    Single Cell Biology: From Development to Cancer

    June 18 – 22, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Gastrointestinal Diseases

    Karolinska Institutet – Stockholm, Sweden

    Research Coordinator – Liver Cancer

    Baylor College of Medicine, Texas, United States

    Postdoctoral Fellow – Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    PhD Student – Early Detection of Liver Cancer

    Helmholtz Association of German Research Centres – Heidelberg, Germany

    Director – Liver Transplant

    University of Utah – Salt Lake City, Utah, United States

    > See All Jobs

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