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| Researchers screened the lysyl-oxidase (LOX) family to clarify its contribution to chemotherapy resistance in liver cancer. LOXL3 depletion significantly sensitized liver cancer cells to oxaliplatin by inducing ferroptosis [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Hepatic stellate cells were a source of neurotrophin-3, which drove hepatocyte proliferation in vitro and in hepatic stellate cell–depleted mice by stimulating the receptor tropomyosin receptor kinase B. [Science Signaling] |
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| Scientists identified tripartite motif-containing protein 21 (TRIM21), a class IV TRIM family member, as a pivotal regulator of hepatic metabolism in type 2 diabetes mellitus. [Cellular And Molecular Life Sciences] |
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| Researchers investigated the role and mechanism of double negative T cells in regulating the Th9 cells differentiation in liver fibrosis. [Liver International] |
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| Scientists evaluated Na+ level in hepatocarcinoma cells and HCC allografts and investigated their sensitivity to a forced Na+ influx induced by the Na+ ionophore in comparison to healthy primary hepatocytes and normal tissues. [Communications Biology] |
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| Researchers revealed cancer-associated fibroblasts (CAF) were associated with hepatocarcinogenesis and the functional importance of B cells and CD8 + T cells in modulating CAF in HCC. [Gut Pathogens] |
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| The expression of BAIAP2L2 in HCC was analyzed using The Cancer Genome Atlas, Gene Expression Omnibus, International Cancer Genome Consortium, and Human Protein Atlas databases and in vitro experiments. [Scientific Reports] |
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| Investigators observed that diacetyl induced α-smooth muscle actin, one of the hallmarks of fibrosis, in an ex vivo cultured hepatic section, but not in in vitro hepatic stellate TWNT-1 cells. [Scientific Reports] |
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| The authors established miRNAs from exosomes associated with liver fibrosis, and to identify potential biomarkers for the prediction of personalized clinical management effectiveness in HCC. [PLOS One] |
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| The risk of cardiovascular disease increases by three to six-fold with the coexistence of diabetes and hypertension; therefore, the management of blood pressure to prevent cardiovascular disease is a particularly important issue in patients with diabetes. [Hypertension Research] |
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| Ezra announced that its newest proprietary artificial intelligence, Ezra Flash, has received 510(k) clearance from the US FDA. Ezra Flash enhances the quality of MR images, making it possible to decrease the time needed to complete a high-quality scan, thereby reducing MRI costs. [Ezra (Business Wire)] |
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| June 25 – 30, 2023 Newry, Maine, United States |
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| University of New South Wales – Sydney, New South Wales, Australia |
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| Karolinska Institutet – Stockholm, Sweden |
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| Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| Helmholtz Association of German Research Centres – Heidelberg, Germany |
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| University of Geneva – Geneva, Switzerland |
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