Hepatic Cell News Volume 7.19 | Jun 02 2023

    By
    Jamie Kang
    -
    0
    17







    2023-06-02 | HCN 7.19


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.19 – 2 June, 2023
    TOP STORY

    Lysyl Oxidase-Like 3 Restrains Mitochondrial Ferroptosis To Promote Liver Cancer Chemoresistance by Stabilizing Dihydroorotate Dehydrogenase

    Researchers screened the lysyl-oxidase (LOX) family to clarify its contribution to chemotherapy resistance in liver cancer. LOXL3 depletion significantly sensitized liver cancer cells to oxaliplatin by inducing ferroptosis
    [Nature Communications]

    Full Article
    Enjoy your weekend. Your cells will too. Reduce medium acidosis with mTeSRâ„¢ Plus.
    PUBLICATIONSRanked by the impact factor of the journal

    Hepatic Stellate Cells Maintain Liver Homeostasis through Paracrine Neurotrophin-3 Signaling That Induces Hepatocyte Proliferation

    Hepatic stellate cells were a source of neurotrophin-3, which drove hepatocyte proliferation in vitro and in hepatic stellate cell–depleted mice by stimulating the receptor tropomyosin receptor kinase B.
    [Science Signaling]

    Abstract

    TRIM21 Ameliorates Hepatic Glucose and Lipid Metabolic Disorders in Type 2 Diabetes Mellitus by Ubiquitination of PEPCK1 and FASN

    Scientists identified tripartite motif-containing protein 21 (TRIM21), a class IV TRIM family member, as a pivotal regulator of hepatic metabolism in type 2 diabetes mellitus.
    [Cellular And Molecular Life Sciences]

    Full Article

    Double-Negative T Cells Regulate the Progression of Liver Fibrosis through Th9 Cells Differentiation

    Researchers investigated the role and mechanism of double negative T cells in regulating the Th9 cells differentiation in liver fibrosis.
    [Liver International]

    Abstract

    Boosting Intracellular Sodium Selectively Kills Hepatocarcinoma Cells and Induces Hepatocellular Carcinoma Tumor Shrinkage in Mice

    Scientists evaluated Na+ level in hepatocarcinoma cells and HCC allografts and investigated their sensitivity to a forced Na+ influx induced by the Na+ ionophore in comparison to healthy primary hepatocytes and normal tissues.
    [Communications Biology]

    Full Article

    Single-Cell RNA Sequencing Reveals the Mediatory Role of Cancer-Associated Fibroblast PTN in Hepatitis B Virus Cirrhosis-HCC Progression

    Researchers revealed cancer-associated fibroblasts (CAF) were associated with hepatocarcinogenesis and the functional importance of B cells and CD8 + T cells in modulating CAF in HCC.
    [Gut Pathogens]

    Full Article

    BAIAP2L2 Is a Novel Prognostic Biomarker Related to Migration and Invasion of HCC and Associated with Cuprotosis

    The expression of BAIAP2L2 in HCC was analyzed using The Cancer Genome Atlas, Gene Expression Omnibus, International Cancer Genome Consortium, and Human Protein Atlas databases and in vitro experiments.
    [Scientific Reports]

    Full Article

    Non-Target GC–MS Analyses of Fecal VOCs in NASH-Hepatocellular Carcinoma Model STAM Mice

    Investigators observed that diacetyl induced α-smooth muscle actin, one of the hallmarks of fibrosis, in an ex vivo cultured hepatic section, but not in in vitro hepatic stellate TWNT-1 cells.
    [Scientific Reports]

    Full Article

    Liver Fibrosis-Derived Exosomal miR-106a-5p Facilitates the Malignancy by Targeting SAMD12 and CADM2 in Hepatocellular Carcinoma

    The authors established miRNAs from exosomes associated with liver fibrosis, and to identify potential biomarkers for the prediction of personalized clinical management effectiveness in HCC.
    [PLOS One]

    Full Article

    Connect with us via LiveChat to ask your scientific support questions
    REVIEWS

    Recent Understandings About Hypertension Management in Type 2 Diabetes: What Are the Roles of SGLT2 Inhibitor, GLP-1 Receptor Agonist, and Finerenone?

    The risk of cardiovascular disease increases by three to six-fold with the coexistence of diabetes and hypertension; therefore, the management of blood pressure to prevent cardiovascular disease is a particularly important issue in patients with diabetes.
    [Hypertension Research]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Ezra Receives 510(k) FDA Clearance For AI That Enhances MRI, Enabling Fast, Low-Cost Scans

    Ezra announced that its newest proprietary artificial intelligence, Ezra Flash, has received 510(k) clearance from the US FDA. Ezra Flash enhances the quality of MR images, making it possible to decrease the time needed to complete a high-quality scan, thereby reducing MRI costs.
    [Ezra (Business Wire)]

    Press Release
    FEATURED EVENT

    Advanced Cell and Tissue Biomanufacturing

    June 25 – 30, 2023
    Newry, Maine, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Officer – HIV, Hepatitis C, and COVID-19

    University of New South Wales – Sydney, New South Wales, Australia

    Research Assistant – Gastrointestinal Diseases

    Karolinska Institutet – Stockholm, Sweden

    Postdoctoral Fellow – Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    PhD Student – Early Detection of Liver Cancer

    Helmholtz Association of German Research Centres – Heidelberg, Germany

    Professorships – Cell Physiology and Metabolism

    University of Geneva – Geneva, Switzerland

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Hepatic Cell News Twitter