Efficient Chimeric Antigen Receptor (CAR) Targeting of a Central Epitope of CD22

Researchers compared m971-CAR with a novel CAR derived from IS7, an antibody that targets a central epitope on CD22. The IS7-CAR has superior avidity, and is active and specific against CD22 positive targets, including B lineage acute lymphoblastic leukemia patient-derived xenograft samples.