| Vol. 4.30 – 3 August, 2023 |
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| Scientists explored the suitability of hepatocyte organoids for Plasmodium falciparum (Pf)-development and showed that these cells permitted parasite invasion, differentiation, and maturation of different Pf strains. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A human stomach micro-physiological system with physiologically relevant gastric mucosal defense system was described based on the combination of organoid and micro-physiological system technology. [Advanced Science] |
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| Hollowed nanocarriers with poly-l-lysine coating and mammalian orthoreovirus cell attachment protein σ1 functionalization were explored as functional oral drug delivery vehicles with gut organoid platforms. [Bioactive Materials] |
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| Researchers investigated the potential of black phosphorous as a targeting PPAR-γ agonist to overcome chemoresistance in the treatment of pancreatic adenocarcinoma using 2D and 3D cell lines, patient-derived organoids, and mouse models. [Advanced Healthcare Materials] |
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| Investigators generated hiPSC-derived retinal organoids of patients with retinitis pigmentosa caused by biallelic CRB1 mutations. [Stem Cell Reports] |
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| Various clinicopathologic factors, including the tumor size, tumor location, clinical stage, histologic subtype, and tumor differentiation, did not influence the patient-derived organoid establishment. [Digestive Endoscopy] |
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| The authors established an hPSC-derived hypothalamus organoid differentiation protocol to model the cellular diversity of this brain region. [iScience] |
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| Investigators examined the growth and neuronal activity in human cortical organoids exposed to buprenorphine or methadone. [Neuropharmacology] |
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| Scientists developed an organoid model more representative of the embryonic palate that included three cell types: mesenchyme, endothelial, and epithelial cells. [Birth Defects Research] |
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| Many reports have described the modeling of various hereditary kidney diseases, with polycystic kidney disease serving as the archetypal disease, by using patient-derived or genome-edited kidney organoids. [Cell Stem Cell] |
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| Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%. [Science Insider] |
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| October 18 – 21, 2023 EMBL Heidelberg and Virtual |
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| Goethe University Frankfurt – Frankfurt, Germany |
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| IRB Barcelona – Barcelona, Spain |
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| Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| The University Hospital Essen – Essen, Germany |
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