Organoid News Volume 4.30 | Aug 3 2023

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    2023-08-03 | ON 4.30


    Organoid News by STEMCELL Technologies
    Vol. 4.30 – 3 August, 2023
    TOP STORY

    Development of Plasmodium falciparum Liver-Stages in Hepatocytes Derived from Human Fetal Liver Organoid Cultures

    Scientists explored the suitability of hepatocyte organoids for Plasmodium falciparum (Pf)-development and showed that these cells permitted parasite invasion, differentiation, and maturation of different Pf strains.
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Organoid-Based Human Stomach Micro-Physiological System to Recapitulate the Dynamic Mucosal Defense Mechanism

    A human stomach micro-physiological system with physiologically relevant gastric mucosal defense system was described based on the combination of organoid and micro-physiological system technology.
    [Advanced Science]

    Full Article

    Rational Design of Oral Drugs Targeting Mucosa Delivery with Gut Organoid Platforms

    Hollowed nanocarriers with poly-l-lysine coating and mammalian orthoreovirus cell attachment protein σ1 functionalization were explored as functional oral drug delivery vehicles with gut organoid platforms.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    Black Phosphorus as a Targeting PPAR-γ Agonist to Reverse Chemoresistance in Patient-Derived Organoids, Mice, and Pancreatic Tumor Cells

    Researchers investigated the potential of black phosphorous as a targeting PPAR-γ agonist to overcome chemoresistance in the treatment of pancreatic adenocarcinoma using 2D and 3D cell lines, patient-derived organoids, and mouse models.
    [Advanced Healthcare Materials]

    Abstract

    CRB1 Is Required for Recycling by RAB11A+ Vesicles in Human Retinal Organoids

    Investigators generated hiPSC-derived retinal organoids of patients with retinitis pigmentosa caused by biallelic CRB1 mutations.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Simultaneous Establishment of Pancreatic Cancer Organoid and Cancer-Associated Fibroblast Using a Single-Pass Endoscopic Ultrasound-Guided Fine Needle Biopsy Specimen

    Various clinicopathologic factors, including the tumor size, tumor location, clinical stage, histologic subtype, and tumor differentiation, did not influence the patient-derived organoid establishment.
    [Digestive Endoscopy]

    Abstract

    Novel Human Pluripotent Stem Cell-Derived Hypothalamus Organoids Demonstrate Cellular Diversity

    The authors established an hPSC-derived hypothalamus organoid differentiation protocol to model the cellular diversity of this brain region.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Buprenorphine and Methadone Differentially Alter Early Brain Development in Human Cortical Organoids

    Investigators examined the growth and neuronal activity in human cortical organoids exposed to buprenorphine or methadone.
    [Neuropharmacology]

    Abstract

    An Improved Multicellular Human Organoid Model for the Study of Chemical Effects on Palatal Fusion

    Scientists developed an organoid model more representative of the embryonic palate that included three cell types: mesenchyme, endothelial, and epithelial cells.
    [Birth Defects Research]

    Abstract
    Explore neural organoid technologies with this free wallchart from STEMCELL and Nature Neuroscience
    REVIEWS

    Advances and Challenges toward Developing Kidney Organoids for Clinical Applications

    Many reports have described the modeling of various hereditary kidney diseases, with polycystic kidney disease serving as the archetypal disease, by using patient-derived or genome-edited kidney organoids.
    [Cell Stem Cell]

    Abstract
    INDUSTRY AND POLICY NEWS

    Senate Panel Approves 2% Bump for NIH Budget in 2024

    Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
    [Science Insider]

    Press Release
    FEATURED EVENT

    Organoids: Modelling Organ Development and Disease in 3D Culture

    October 18 – 21, 2023
    EMBL Heidelberg and Virtual

    > See All Events

    JOB OPPORTUNITIES

    Professor – Systems Neurobiology

    Goethe University Frankfurt – Frankfurt, Germany

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

    Research Laboratory Technician – Organoids & Placentation

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    Postdoctoral Research Fellow – Role of AHR in Mediating Barrier Tissue Homeostasis

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Researcher – Clinic of Ophthalmology

    The University Hospital Essen – Essen, Germany

    > See All Jobs

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