| Vol. 15.30 – 11 August, 2023 |
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| Using single-cell and bulk transcriptional and metabolic analyses in combination with cell-specific gene perturbation studies, researchers identified a regulatory loop of negative feedback that operated in dendritic cellss to limit immunopathology. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Surface protein sushi domain containing 6 was abundantly expressed in acute myeloid leukemia and multiple solid cancers, and its ablation enhanced major histocompatibility complex class I (MHC-I) antigen presentation and reduced tumor growth in a CD8+ T cell-dependent manner. [Cell] |
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| Through unbiased CRISPR screens, the authors established dsRNA-sensing and interferon signaling were primary mediators that potentiated T-cell killing of cancer cells following METTL3 inhibition. [Cancer Discovery] |
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| Mice with T cell–specific deficiency of Pla2g12a failed to develop disease in an experimental autoimmune encephalomyelitis model of multiple sclerosis. [Science Immunology] |
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| Mechanistically, forkhead box O1 (FOXO1) promoted the transcription of neuropeptide receptor VIPR2 and inhibited the transcription of adrenoceptor ADRA2A in group 3 innate lymphoid cells. [Journal Of Experimental Medicine] |
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| Researchers generated αPD-1 resistant variants of the murine head and neck squamous cell carcinoma model MEER. While entirely αPD-1 resistant, these tumors regressed after single dose of oncolytic vaccinia virus . [Journal Of Experimental Medicine] |
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| The authors presented a deep learning framework, termed DeepAIR, for the accurate prediction of adaptive immune receptors (AIRs)-antigen binding by integrating both sequence and structure features of AIRs. [Science Advances] |
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| Scientists assessed the impact of a standard topical corticosteroid treatment, triamcinolone acetonide, on the formation, maintenance, and reactivation of epidermal tissue-resident memory T cells in a preclinical model of allergic contact dermatitis to 2,4-dinitrofluorobenzene. [Allergy] |
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| Researchers showed that T cell–specific CD47-deficient mice had a markedly reduced number of T cells in peripheral tissues. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors discuss the molecular mechanisms that regulate receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to maintain homeostasis and cellular survival in healthy cells, yet drive cell death in a context-dependent manner. [Nature Reviews Molecular Cell Biology] |
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| Scientists address how the gut microbiota can profoundly influence neural and immune networks. Although many of the interactions between these three systems originate in the intestinal mucosa, intestinal function and immunity are modulated by neural pathways that connect the gut and brain. [Immunity] |
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The FDA also confirmed no additional randomized, placebo-controlled trial will be required to support submission of a biologics license application. [Precigen Inc.] |
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| September 20 – 23, 2023 Milan, Italy |
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| Technical University of Denmark – Kongens Lyngby, Denmark |
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| The University of Copenhagen – Copenhagen, Denmark |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| Stanford University – Stanford, California, United States |
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| Institut Pasteur – Paris, France |
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