Immune Regulation News Volume 15.30 | Aug 11 2023

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    Laurisa Dohm
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    2023-08-11 | IRN 15.30


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.30 – 11 August, 2023
    TOP STORY

    Lactate Limits CNS Autoimmunity by Stabilizing HIF-1α in Dendritic Cells

    Using single-cell and bulk transcriptional and metabolic analyses in combination with cell-specific gene perturbation studies, researchers identified a regulatory loop of negative feedback that operated in dendritic cellss to limit immunopathology.
    [Nature]

    AbstractPress Release
    Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    A Membrane-Associated MHC-I Inhibitory Axis for Cancer Immune Evasion

    Surface protein sushi domain containing 6 was abundantly expressed in acute myeloid leukemia and multiple solid cancers, and its ablation enhanced major histocompatibility complex class I (MHC-I) antigen presentation and reduced tumor growth in a CD8+ T cell-dependent manner.
    [Cell]

    AbstractGraphical Abstract

    Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Anti-Tumor Immunity

    Through unbiased CRISPR screens, the authors established dsRNA-sensing and interferon signaling were primary mediators that potentiated T-cell killing of cancer cells following METTL3 inhibition.
    [Cancer Discovery]

    AbstractPress Release

    1-Oleoyl-Lysophosphatidylethanolamine Stimulates RORγt Activity in TH17 Cells

    Mice with T cell–specific deficiency of Pla2g12a failed to develop disease in an experimental autoimmune encephalomyelitis model of multiple sclerosis.
    [Science Immunology]

    Abstract

    FOXO1 Orchestrates the Intestinal Homeostasis via Neuronal Signaling in Group 3 Innate Lymphoid Cells

    Mechanistically, forkhead box O1 (FOXO1) promoted the transcription of neuropeptide receptor VIPR2 and inhibited the transcription of adrenoceptor ADRA2A in group 3 innate lymphoid cells.
    [Journal Of Experimental Medicine]

    Abstract

    An Oncolytic Virus–Delivered TGFβ Inhibitor Overcomes the Immunosuppressive Tumor Microenvironment

    Researchers generated αPD-1 resistant variants of the murine head and neck squamous cell carcinoma model MEER. While entirely αPD-1 resistant, these tumors regressed after single dose of oncolytic vaccinia virus .
    [Journal Of Experimental Medicine]

    Full ArticleGraphical
    Abstract

    DeepAIR: A Deep Learning Framework for Effective Integration of Sequence and 3D Structure to Enable Adaptive Immune Receptor Analysis

    The authors presented a deep learning framework, termed DeepAIR, for the accurate prediction of adaptive immune receptors (AIRs)-antigen binding by integrating both sequence and structure features of AIRs.
    [Science Advances]

    Full Article

    Topical Corticosteroids Inhibit Allergic Skin Inflammation but Are Ineffective in Impeding the Formation and Expansion of Resident Memory T Cells

    Scientists assessed the impact of a standard topical corticosteroid treatment, triamcinolone acetonide, on the formation, maintenance, and reactivation of epidermal tissue-resident memory T cells in a preclinical model of allergic contact dermatitis to 2,4-dinitrofluorobenzene.
    [Allergy]

    Abstract

    CD47 Promotes Peripheral T Cell Survival by Preventing Dendritic Cell–Mediated T Cell Necroptosis

    Researchers showed that T cell–specific CD47-deficient mice had a markedly reduced number of T cells in peripheral tissues.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Roles of RIPK1 as a Stress Sentinel Coordinating Cell Survival and Immunogenic Cell Death

    The authors discuss the molecular mechanisms that regulate receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to maintain homeostasis and cellular survival in healthy cells, yet drive cell death in a context-dependent manner.
    [Nature Reviews Molecular Cell Biology]

    Abstract

    Boundaries and Integration between Microbiota, the Nervous System, and Immunity

    Scientists address how the gut microbiota can profoundly influence neural and immune networks. Although many of the interactions between these three systems originate in the intestinal mucosa, intestinal function and immunity are modulated by neural pathways that connect the gut and brain.
    [Immunity]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Precigen Announces FDA Confirmation that the Ongoing Phase I/II Study of PRGN-2012 AdenoVerse Immunotherapy Will Serve as the Pivotal Study to Support Accelerated Approval

    The FDA also confirmed no additional randomized, placebo-controlled trial will be required to support submission of a biologics license application.
    [Precigen Inc.]

    Press Release
    FEATURED EVENT

    Seventh International Cancer Immunotherapy Conference: Translating Science into Survival

    September 20 – 23, 2023
    Milan, Italy

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Engineering of iPSC-NK cells

    Technical University of Denmark – Kongens Lyngby, Denmark

    Postdoctoral Position – Modeling of the Tumor Microenvironment

    The University of Copenhagen – Copenhagen, Denmark

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Assistant/Associate Professor – Immunology of Pancreatic Disorders

    Stanford University – Stanford, California, United States

    Postdoctoral Researcher – Skin Inflammation & Regenerative Disease

    Institut Pasteur – Paris, France

    > See All Jobs

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