| Vol. 15.32 – 25 August, 2023 |
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| High-molecular-mass hyaluronic acid reduced inflammation through several pathways, including a direct immunoregulatory effect on immune cells, protection from oxidative stress, and improved gut barrier function during aging. [Nature] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Specific deletion of the nuclear isoform of retinoic acid receptor alpha (RARα) revealed an RARα isoform in the cytoplasm of T cells. Extranuclear RARα was rapidly phosphorylated upon T cell receptor stimulation and recruited to the T cell receptor signalosome. [Immunity] |
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| The authors established an in vitro model of chronic stimulation and benchmarked key phenotypic, functional, transcriptional, and epigenetic features against bona fide in vivo exhausted CD8 T cells. [Science Immunology] |
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| Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). Researchers analyzed via single-cell omics the trajectory leading to LatY136F DLSP, and the underlying CD4+ T cell diversification. [Journal Of Experimental Medicine] |
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| Whole tumor single-cell RNA sequencing analysis and blockade experiments revealed that the amphiregulin–epidermal growth factor receptor axis mediated cross-talk between IL1RL1+ Treg cells and cancer-associated fibroblasts. [Science Advances] |
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| Investigators found that tumor necrosis factor–like cytokine 1A/death receptor 3 promoted helper T (Th) 1 and Th7 cell differentiation in T-T and dendritic cell-T cell interaction-dependent manners. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors investigated the impact of acute colitis on tumor infiltration of antigen-specific CD8+ cytotoxic T lymphocytes for controlling tumor growth and responding to antibody against PD-1. [BMC Medicine] |
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| To understand the functional impact of mutations across FoxP3 domains, without genetic and environmental confounders, six human FOXP3 missense mutations were engineered into mice. [Cell Reports] |
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| Using an antibody against CD25 that biases IL-2 signaling toward an alternative pathway, researchers established that IL-2 signaling via an alternative CD25-chemokine receptor pathway increased the suppressive activity of Tregs and ameliorated murine experimental autoimmune encephalomyelitis. [Cell Reports] |
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| Cell death by phagocytosis mediates physiological turnover of erythrocytes and other leucocytes, making it the most abundant form of cell death in the mammalian body. [Nature Reviews Immunology] |
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| Scientists review key concepts and recent advances in our understanding of the RNA circuits and RNA-binding proteins that govern mammalian T cell differentiation and immune function. [Trends In Immunology] |
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| The FDA endorsed Novartis’ Tyruko as the first US biosimilar to treat multiple sclerosis (MS). The new treatment covers all of Tysabri’s indications for relapsing MS, in addition to Crohn’s disease. [Fierce Pharma] |
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| September 24 – 27, 2023 Glasgow, Scotland |
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| The Scripps Research Institute – La Jolla, California, United States |
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| University of Regensberg – Heidelberg, Germany |
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| University of Missouri – Columbia, Missouri, United States |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| Institut Pasteur – Paris, France |
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