Immune Regulation News Volume 15.32 | Aug 25 2023

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    Laurisa Dohm
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    2023-08-25 | IRN 15.32


    Immune Regulation News by STEMCELL Technologies
    Vol. 15.32 – 25 August, 2023
    TOP STORY

    Increased Hyaluronan by Naked Mole-Rat Has2 Improves Healthspan in Mice

    High-molecular-mass hyaluronic acid reduced inflammation through several pathways, including a direct immunoregulatory effect on immune cells, protection from oxidative stress, and improved gut barrier function during aging.
    [Nature]

    AbstractPress Release
    Explore Antibodies for Immunology Research
    PUBLICATIONSRanked by the impact factor of the journal

    A Regulatory Circuit Controlled by Extranuclear and Nuclear Retinoic Acid Receptor α Determines T Cell Activation and Function

    Specific deletion of the nuclear isoform of retinoic acid receptor alpha (RARα) revealed an RARα isoform in the cytoplasm of T cells. Extranuclear RARα was rapidly phosphorylated upon T cell receptor stimulation and recruited to the T cell receptor signalosome.
    [Immunity]

    AbstractGraphical Abstract

    In Vitro Modeling of CD8+ T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

    The authors established an in vitro model of chronic stimulation and benchmarked key phenotypic, functional, transcriptional, and epigenetic features against bona fide in vivo exhausted CD8 T cells.
    [Science Immunology]

    Full Article

    Defective LAT Signalosome Pathology in Mice Mimics Human IgG4-Related Disease at Single-Cell Level

    Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). Researchers analyzed via single-cell omics the trajectory leading to LatY136F DLSP, and the underlying CD4+ T cell diversification.
    [Journal Of Experimental Medicine]

    Full Article

    Amphiregulin Couples IL1RL1+ Regulatory T Cells and Cancer-Associated Fibroblasts to Impede Antitumor Immunity

    Whole tumor single-cell RNA sequencing analysis and blockade experiments revealed that the amphiregulin–epidermal growth factor receptor axis mediated cross-talk between IL1RL1+ Treg cells and cancer-associated fibroblasts.
    [Science Advances]

    Full Article

    Tumor Necrosis Factor–Like Cytokine 1A Plays a Role in Inflammatory Bowel Disease Pathogenesis

    Investigators found that tumor necrosis factor–like cytokine 1A/death receptor 3 promoted helper T (Th) 1 and Th7 cell differentiation in T-T and dendritic cell-T cell interaction-dependent manners.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Abnormal Generation of IL-17A Represses Tumor Infiltration of Stem-Like Exhausted CD8+ T Cells to Demote the Antitumor Immunity

    The authors investigated the impact of acute colitis on tumor infiltration of antigen-specific CD8+ cytotoxic T lymphocytes for controlling tumor growth and responding to antibody against PD-1.
    [BMC Medicine]

    Full Article

    Mutations from Patients with IPEX Ported to Mice Reveal Different Patterns of FoxP3 and Treg Dysfunction

    To understand the functional impact of mutations across FoxP3 domains, without genetic and environmental confounders, six human FOXP3 missense mutations were engineered into mice.
    [Cell Reports]

    Full ArticleGraphical Abstract

    IL-2 Can Signal via Chemokine Receptors to Promote Regulatory T Cells’ Suppressive Function

    Using an antibody against CD25 that biases IL-2 signaling toward an alternative pathway, researchers established that IL-2 signaling via an alternative CD25-chemokine receptor pathway increased the suppressive activity of Tregs and ameliorated murine experimental autoimmune encephalomyelitis.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Tools and products for your COVID-19 research.
    REVIEWS

    Cell Death by Phagocytosis

    Cell death by phagocytosis mediates physiological turnover of erythrocytes and other leucocytes, making it the most abundant form of cell death in the mammalian body.
    [Nature Reviews Immunology]

    Abstract

    RNA Circuits and RNA-Binding Proteins in T Cells

    Scientists review key concepts and recent advances in our understanding of the RNA circuits and RNA-binding proteins that govern mammalian T cell differentiation and immune function.
    [Trends In Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Novartis Wins FDA Nod for First Biosimilar Version of Biogen’s MS Blockbuster Tysabri

    The FDA endorsed Novartis’ Tyruko as the first US biosimilar to treat multiple sclerosis (MS). The new treatment covers all of Tysabri’s indications for relapsing MS, in addition to Crohn’s disease.
    [Fierce Pharma]

    Editorial
    FEATURED EVENT

    17th Vaccine Congress

    September 24 – 27, 2023
    Glasgow, Scotland

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Immunology & Microbiology

    The Scripps Research Institute – La Jolla, California, United States

    Professorship – Immune Cell & Tissue Interactions

    University of Regensberg – Heidelberg, Germany

    Postdoctoral Fellow – Autoimmunity & Transplantation

    University of Missouri – Columbia, Missouri, United States

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Researcher – Skin Inflammation & Regenerative Disease

    Institut Pasteur – Paris, France

    > See All Jobs

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