USP39 Promotes Hepatocellular Carcinogenesis through Regulating Alternative Splicing in Cooperation with SRSF6/HNRNPC

Investigators observed that hepatocyte-specific overexpression of ubiquitin-specific protease 39 (USP39) promoted hepatocarcinogenesis and potently regulated splice site selection in transgenic mice. In human liver cancer cells, USP39 promoted tumor proliferation in a spliceosome-dependent manner.