| Vol. 14.42 – 24 October, 2023 |
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| High-density immunophenotyping of AML coupled with proteogenomics identified unique expression of a variety of antigens, including the RNA helicase U5 snRNP200, on the surface of AML cells. [Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that in contrast to mixed AML and T cell malignancy developed in NrasG12D/+; p53-/- mice, NrasG12D/+; p53R172H/+ mice rapidly developed an inflammation-associated AML. [Journal Of Clinical Investigation] |
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| Using a mouse model of emergency granulopoiesis, the authors observed transcriptional changes in HSCs as early as four hours after lipopolysaccharide administration. [EMBO Journal] |
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| Scientists investigated erythropoiesis and the development of myelodysplasia in mouse models of iron overload and compromised antioxidant response. [Leukemia] |
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| Investigators demonstrated that the myeloproliferative phenotype in double knockout mice correlated with an increase of hematopoietic stem and progenitor cells early in life. [Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers found that systemic single injections of Akkermansia muciniphila, a mucin-degrading bacterium, rapidly activated bone marrow myelopoiesis and slowed long-lasting hepato-splenomegaly. [EMBO Reports] |
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| Investigators identified a novel zinc finger protein X-linked (ZFX)/WNT3 axis that modulated the growth and imatinib mesylate response of chronic myeloid leukemia stem/progenitor cells. [Cellular & Molecular Biology Letters] |
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| Scientists analyzed clinical data and differentially expressed miRNAs in CD34+ chronic myeloid leukemia cells from 80 patients at diagnosis who were later classified as imatinib-responders or imatinib-nonresponders. [Leukemia] |
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| Researchers found that low serum interferon-γ (IFN-γ) levels correlated with a higher percentage of leukemia stem cells and greater relapse incidence in AML patients. [Oncogene] |
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| Scientists discuss the key principles of deregulation of epigenetic processes that shape leukemia stem cells’ evolution. They also discuss efforts to identify mechanisms of resistance, by longitudinal analysis of patient samples. [Molecular Oncology] |
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BioFlorida has named Stephen D. Nimer, MD, director of Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, “Researcher of the Year.” [University of Miami Miller School of Medicine] |
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| November 7 – 8, 2023 London, England, United Kingdom |
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| Cedars-Sinai – Los Angeles, California, United States |
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| Cedars-Sinai – Los Angeles, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Georgetown University – Washington, Pennsylvania, United States |
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| University of San Francisco – San Francisco, California, United States |
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